Other Life Sciences Commons^™

Stereospecific Cross-Coupling Reactions Of Enantioenriched Secondary Alkyltricyclohexyltin Nucleophiles, Meruyert Binayeva

Dissertations, Theses, and Capstone Projects

Transition metal-catalyzed cross-coupling reactions have evolved into a remarkable instrument for the formation of new bonds, and have significantly impacted how we approach to access complex organic molecules. Palladium is currently one of the most popular elements for catalytic applications due to its ability to facilitate powerful carbon-carbon and carbon-heteroatom couplings. Traditional Pd-catalyzed cross-coupling reactions have primarily concentrated on C(sp2)-C(sp2) cross-couplings, yielding planar products. Considering the use of C(sp3) nucleophiles would offer a viable control of the three dimensional arrangement in molecules. Herein, the first chapter details the history and development of Pd-catalyzed Stille cross-coupling reactions. The use of configurationally …

Investigating Ammonium Toxicity In The Performance Of Recirculating Periphytic Algal Wastewater Treatment Systems, Oluchuku Richie Ochonogor

Theses and Dissertations

Freshwater nutrient enrichment from wastewater facilities and other sources can lead to freshwater eutrophication, a threat to global aquatic ecosystems. Mechanical and chemical ways to curb this threat are either too expensive or not sustainable, and thus, not feasible. Compared to mechanical and other methods, sustainable, inexpensive biological methods (for example, algal treatment systems) have therefore been developed for the removal of excess nutrients from wastewater. By design, secondary waste treatment facilities (WWTF) remove organics and solids and lower oxygen demanding substances; however, they may not remove enough nutrients to protect freshwater ecosystems in all cases. While algae-based biological methods …

Exploiting Vulnerabilities In The Ras-Rac Signaling Pathway For The Selective Targeting Of Pancreatic Cancer Cells, Neha Chaudhary

Theses & Dissertations

Deregulation of the KRas (Kirsten rat sarcoma virus) GTPase is one of the early hallmarks of Pancreatic Cancer (PC). The most common genetic alteration found in PC are mutations in the KRas protein that block its ability to hydrolyze GTP to GDP and resulting in higher levels of GTP-bound KRas, its active form. Pancreatic tumors driven by oncogenic mutants of KRas tend to be addicted to the oncogene, to the extent that its repression leads to the induction of cell death. This addiction to the KRAS oncogene makes the KRas protein an ideal target for cancer therapy. However, the globular …

Generation Z’S Perceptions Of Hunting And Conservation Efforts In Arkansas, Hannah Ferguson

Graduate Theses and Dissertations

Hunting participation numbers have steadily declined since the 1980s and Generation Z is not engaging in hunting. Hunting is one of the most effective tools for managing wildlife populations and ensuring the success and local ecosystem conservation. Many wildlife stewardship institutions, such as Arkansas Game and Fish Commission in Arkansas, are funded by sales taxes imposed on firearms, ammo, and archery equipment. With a decline in hunting participation, it is imperative state-run wildlife stewardship organizations and other hunting institutions learn the best practices for communicating with younger generations. This study sought to understand Generation Z’s perceptions of hunting and conservation …

Eco-Interoception: What Plants, Fungi And Protista Have Taught My Body, Sara Riley Dotterer

Art Theses and Dissertations

To me, ecology is the relational, full-body awareness that I am made up of and deeply connected to everything around me; and for better or worse, this is reciprocal. I form ecotones, an ecological transitional zone between two ecosystems, with the world around me. I use this ecotonal lens to blur binaries and dissolve boundaries between me and the world “outside my body.” During my Masters of Fine Arts at Southern Methodist University, I have continuously explored and represented the lives of various more-than-human species outside of my body, including plants, fungi and protista through an ecotonal lens. Although these …

Elsewhere: In Defense Of Daydreaming, Alex Braden

MFA in Visual Art

Much like music, organic life is an absurd, improbable, and serendipitous instance. I set circular, electric, acoustic, and magnetic forces in motion and allow them to coalesce freely in the hopes of synthesizing unexpected moments of beauty, connection, and harmony.

Enhancing The Quality Of Life For Senior Citizens: A Facilitator’S Guidebook For Mindful Music And Movement, Shannon Sexton

Mindfulness Studies Theses

Music appreciation and enjoyment enhance well-being throughout the lifespan. The challenges and constraints that people experience as they age can lead to lack of access to music, decreased physical activity, and fewer avenues for creative expression. Group music and movement interventions created for older populations offer opportunities for social connection and improved quality of life. Mindful practices add further benefit when combined with these interventions. Current available programs are scarce and most often do not encompass mixed modalities. In addition, the benefits of these programs do not show long-term sustainability. The purpose of this thesis is to explore the effects …

Selenium Form-Induced Changes In The Early Luteal Phase Corpus Luteum, The Blood, And The Endometrium During Early Gestation In Beef Cows, Sarah Nancy Carr

Theses and Dissertations--Animal and Food Sciences

Selenium (Se) deficient soils and thus forages are widespread throughout the United States, necessitating supplementation of this trace mineral in the diet of grass-fed cattle to negate detrimental effects of a deficiency on immune function, growth, and fertility. Conventionally, Se is supplemented to cattle in a vitamin-mineral mix as an inorganic form (ISe) although the organic forms (OSe) are available when cattle consumer forage, and OSe has been shown to increase the bioavailability of Se in cattle. Previous research has demonstrated supplementation with 1:1 mixture (MIX) of ISe and OSe compared to ISe alone increases systemic concentrations of progesterone (P4) …

A Picture Worth A Thousand Words: Factors Influencing Disability Accommodations, Alicia E. Martin

Cal Poly Humboldt theses and projects

Because not all disabilities look the same it is difficult to label a person with disabilities just by looking at them. Given that our knowledge, attitudes, and perceptions impact how we interpret our world and our willingness to act, people, including professors, may be biased toward providing accommodations for those with easily recognizable disabilities and biased against those with non-recognizable disabilities, and this may impact the disabled person’s ability to learn. This thesis aims to address whether professors’ disability-related attitudes, perceptions of accommodation reasonableness, and willingness to provide accommodations differ when the disability is recognizable (student is pictured in a …

The Relationship Between Alpha-Defensin 1 And Gut Microbiome Composition In A Population Of Bhutanese Refugee Adults With A High Prevalence Of Type 2 Diabetes, Daisha Alana Drake

Honors Theses and Capstones

The New Hampshire Bhutanese refugee population is disproportionately affected by obesity and metabolic disorders such as type 2 diabetes. The gut microbiome is important for overall human health, with high microbial richness and diversity being associated with reduced chronic inflammation and type 2 diabetes risk. Microbial richness and diversity have been shown to decrease in United States (U.S.) immigrant populations, but have not been measured in refugee populations. One of the anti-inflammatory functions of the gut microbiome is related to the production of short-chain fatty acids (SCFAs), which regulate pro-inflammatory cytokine production. Alpha-defensin 1 is an antimicrobial peptide that is …

Distribution And Relative Abundance Of Reintroduced Atlantic Salmon, Salmo Salar, In Lake Ontario Tributaries Using Environmental Dna, Nabeelah Lulat

Electronic Theses and Dissertations

Plans to reintroduce Atlantic salmon in Lake Ontario tributaries consists of stocking hatchery-reared fish yearly which will help to achieve a self-sustaining population. The issue with reintroduction remains in understanding the distribution of fishes after stocking. Environmental DNA (eDNA) provides a sensitive approach for monitoring that can offer inferences into fish distribution. I determined the distribution of stocked Atlantic salmon downstream from stocking sites using qRT-PCR and metabarcoding. I found that Atlantic salmon eDNA detection was more sensitive using qRT-PCR (51%) versus metabarcoding HTS (18.3%). However, metabarcoding provided data on fish community assemblages, which can help to monitor ecological interactions. …

Estudio De La Dieta De Procambarus Clarkii En El Distrito De Riego Del Alto De Chicamocha En El Municipio De Tibasosa, Boyacá., Danna Valentina Castañeda, Laidy Catherin Ocampo Rojas

Biología

La presencia de especies invasoras ocasiona impactos en los ecosistemas donde son introducidas. Cuentan con adaptaciones que les permiten tolerar amplios rangos de condiciones ambientales, facilitando su reproducción y mantenimiento a lo largo de diversas regiones. Procambarus clarkii, un crustáceo perteneciente al orden Decápoda de la familia Cambaridae, llamado como cangrejo de río o cangrejo americano, el cual se encuentra distribuido en varias zonas a nivel nacional, generando un impacto negativo en diferentes ecosistemas colombianos. El objetivo de este trabajo es definir la dieta de Procambarus clarkii en cada uno de sus estadios que se encuentren presentes, además de identificar …

Vegetation And Nutritional Changes Over 20 Years Of White-Tailed Deer Exclusion, Gabrielle Nicole Ripa

Theses and Dissertations

Knowledge of the impacts of white-tailed deer (Odocoileus virginianus; hereafter deer) as dominant herbivores throughout the Southeastern United States of America is lacking. To address this, three paired experimental units of exclosures and controls were constructed in 2000 on three Wildlife Management Areas across Mississippi within the ecoregions of the Upper Coastal Plain, Lower Coastal Plain, and the Mississippi Alluvial Valley. Vegetation was sampled in the summers of 2000, 2005, and 2021 including vegetation structure, canopy coverage, basal area, and species composition. Additionally, in 2005 and 2021, biomass was sampled to determine potential impacts on nutritional carrying capacity. Among the …

X-Ray Interrogated Implantable Chemical And Strain Sensors For Monitoring Implant Associated Infections And Fracture Healing, Apeksha Rajamanthrilage

All Dissertations

Bone fracture healing includes complex and sequence of dynamic events to restore the integrity and biomechanical properties of the bone. While most of the fractures heal without any problem, healing is sometimes compromised. Two significant fracture healing complications are orthopedic implant-associated infections and non-unions/delayed union. These can be interrelated causes as well. Implant-associated infection can cause implant loosening, and as a result, it can delay the fracture healing process. Herein, we describe two different types of sensors that can be used in monitoring biochemical and biomechanical processes of fracture healing using X-rays.

We developed a XELCI (X-ray Excited Luminescence Chemical …

The Microscopical Evidence Traces Analysis Of Household Dust And Its Statistical Significance As A Definitive Identification Technique, Stephanie Polifroni

Dissertations, Theses, and Capstone Projects

Evidence found at crime scenes is used to assist in creating a link the suspect, the victim, and the scene. As stated by the Locard’s Principle, every contact leaves a trace, that evidence can be used to link together an investigation. Traces are collected in hopes that they can be identified and associated to an individual or individuals to help solve that particular crime. However, the strongest conclusion for evidence traces is an association to a source, and unless a physical match of some kind is found, an individualization cannot be established even when known sample is available. However, having …

A Study Of Red Snapper (Lutjanus Campechanus) Ecology In The Northern Gulf Of Mexico And The Effect Of Variable River Outflow Using Stable Isotope Analysis Of The Food Web And Eye Lenses, Caitlin C. Slife

Dissertations

In the Mississippi Bight and surrounding waters, river outflow impacts the basal resources of the Red Snapper food web, altering carbon sources and impacting prey and predator isotopes. In this study, the impact of riverine outflow on nutrients, particulate organic matter (POM), and physical water parameters on Red Snapper and their food web was analyzed using stable isotope and stomach content analysis over 5 years. The Mississippi, Pearl, Pascagoula, and Mobile rivers were included in the analysis of river impact. The Mississippi and Mobile rivers were found to significantly impact nutrients and POM in the region. River outflow was also …

An Overview Of The Extracurricular Polysaccaride Production Of Probiotic Lactic Acid Bacteria, Olujimi Babajide Olowokere

Theses (2016-Present)

The study focuses on a comprehensive review of lactic acid bacteria and their production of extracellular polysaccharide substrates (EPS). Two important factors are addressed in the work; and these are 1) identification of LAB stains found in the commercially sold daily milk, 2) significant factors impacting polysaccharide production. Motivation behind these focus points is to allow further inquiries and studies on exploring these strains of bacteria for human wellness promotion. With microbial EPS production being a recent interest of study among healthcare and food industries sectors, new species of bacteria are extensively exploited for further investigation to improve human health, …

Utility Of The Motivation To Change Lifestyle And Health Behaviors For Dementia Risk Reduction Scale (Mclhb-Drr) Based On A North American Sample, Angelina E. Witbeck

Dissertations

As the population ages, the prevalence rates of dementia continue to increase. Without a cure or promising treatment for dementia, the best course of lowering the prevalence rates of dementia is through preventative measures. Through an electronic survey, the study utilized the MCLHB-DRR scale to determine whether (1) gender, age, educational background, and socioeconomic status will impact the motivational factors to change lifestyle and health behaviors to reduce the risk of developing dementia and (2) direct experiences with individuals that have a dementia diagnosis are likely to impact one's motivational factors to change lifestyle and health behaviors to reduce the …

Approach To Dual Base And Sugar Modification Of Adenosine, Cross-Dehydrogenative Coupling Reactions Of Quinazolinones, And A Novel Entry To Carbazolones And Indolones, Dellamol Sebastian

Dissertations, Theses, and Capstone Projects

Analogues of purine nucleosides are of interest due to their antiviral, antibacterial, and anticancer properties. Although there are large number of reports on C6-modification of 6-chloropurine nucleosides with alkyl amines via the S_NAr reaction pathway, there are fewer reports on comparable reactions with aryl amines. Notably, S_NAr reactions of 6-chloropurine nucleosides with electron-deficient aryl amines is a relatively understudied area. A simple method has been developed for the S_NAr reactions of 6-chloropurine ribonucleosides with electron-deficient-, electron-rich-, and electronically neutral aryl amines. Under the developed conditions, S_NAr reactions of 2’,3’,5’-O-(tert …

Identifying Optimal Stocking Strategies To Support Recovery Of An Endemic Lake Sucker, Dale R. Fonken

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Endemic fishes in the intermountain west experienced significant population declines in the 20th century due to a variety of disturbances, including habitat fragmentation, water development, and the introduction of non-native, predatory fish species. The combination of habitat degradation with increased predation risk can severely limit natural recruitment for native fish species, and in response, fisheries managers have employed a variety of recovery strategies to prevent extinction. Among the most prominent strategies is artificial propagation and subsequent release of individuals into the natural environment (i.e., stocking). Artificial propagation is an expensive endeavor, and when not coupled with a research component, can …

Comparing Multiple Approaches To Reconstructing The Phosphorus History Of Marl Lakes: A Utah Lake Case Study, Mark R. Devey

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Freshwater lakes around the world have suffered from the increasing occurrence of harmful algal blooms in recent decades. One of the most pressing reasons water quality managers try to address harmful algal blooms is that some of the species that occur with them produce toxins which can affect humans, pets, and wildlife. In many lakes, the nutrient phosphorus controls whether these harmful algal and bacterial species can occur. Therefore, efforts to control harmful algal blooms often center around reducing inputs of phosphorus from a variety of sources within the watershed. Scientists and water quality managers have long been challenged by …

Atrazine Levels In Rural Nebraska Counties And Parkinson's Disease, Muhammad Zahid

Capstone Experience

Parkinson's disease (PD) is a multifactorial disorder, connecting both genetic susceptibility and environmental risk factors. Several epidemiological and experimental studies support the evidence that pesticides exposure is positively associated with enhancing neurodegenerative diseases. The high amount of atrazine used in Nebraska and increased PD cases led us to evaluate the association between the long-lived water-soluble pesticide atrazine and PD in Nebraska counties. A person's exposure to atrazine may come from inhalation, dermal absorption, and ingestion. Three types of atrazine data covering 1992 to 2017 were used for this study: applied atrazine, atrazine in surface water, and atrazine in groundwater. In …

How Corrective Lens Choices Are Associated With The Self-Esteem Of College Students, Margaret Neenan

Honors Projects

If you wear glasses or contacts, which one do you wear more often, and why? How Corrective Lens Choices are Associated with the Self-Esteem of College Students is an observational study on 1) how corrective lens choices are associated with the self-esteem of college students, and 2) how do factors such as gender, ethnicity, finances, insurance, recreational and occupational use, or lens options recommended to a patient impact an individual’s choice of corrective lenses. The observational study shows that there is no significant difference in the self-esteem of college students who wore a specific corrective lens more often. However, research …

Mytrials: Clinical Trial Application Concept, Katie Hollister

Graphic Communication

A clinical trial’s success is dependent upon whether a patient attends their highly-structured clinical trial visit schedule, which may include both in-person clinic visits and virtual check-in visits. MyTrials is a clinical trial journey app prototype that enables patients to schedule, reschedule, and attend join their in-person or virtual clinic visits. This product seeks to reduce the burden that scheduling places on the patient, and provides trial-provided resources and a daily and weekly timeline to help patients navigate their clinical trial journey.

Chronic Adolescent Stress As A Predictive Factor For The Risk Of Developing Ptsd-Like Symptoms In Adulthood, Grace K. Young

Theses and Dissertations

Post-traumatic stress disorder is a stress and trauma based psychological disorder that is defined by the DSM-IV as an anxiety disorder that affects approximately 7.8% of people in the United States. PTSD is when those who suffer a traumatic event have intense and distressing feelings, emotions, and memories for a prolonged period of time after the event. A prominent feature of PTSD is the impaired ability to properly extinguish a fear response after a dangerous trigger or stressor is no longer present, also known as safety learning. Stressors are threats perceived within the environment that activate a response within the …

Responses Of Arthropods To Fire And How Pollinators And Pollination Services Are Affected By Fire Severity, Blyssalyn V. Bieber

Electronic Theses and Dissertations

Fires impact ecosystems globally and due to climate change, there are shifts in fire regimes that impact ecological communities which provide essential ecosystem services. Focusing on arthropods, fire can influence this ubiquitous animal group in various way. We performed a comprehensive meta-analysis evaluating how fires impact differing arthropod functional groups. We found that overall, fire negatively effects community level responses for most functional groups with herbivores as the only exception showing some positive effects of fire. We also studied mixed-severity fires that burned >20 years ago and compared floral visitor communities across fire severities. We implemented a pollinator exclusion experiment …

Public Perceptions Of Human Physical Interactions, Exhibition, And Conservation Of Tigers And Cheetahs, Abbie Knudsen

MSU Graduate Theses

Tigers and cheetahs are common in the pet trade, public exhibits, and hands-on encounters with the public. Poor regulation of these experiences has resulted in numerous incidents worldwide in which a person was seriously injured or killed by captive big cats. Additionally, concerns for animal welfare have been raised by industry professionals. Prior research on primates has demonstrated exposing people to photographs of cats in different backgrounds can influence their attitudes about animals in captivity, but no study has addressed whether visual images affect human attitudes toward big cats. I used a survey that asked a series of questions about …

Applying Artificial Intelligence In The Hotel Industry: Exploring Perspectives Of Employees, Logan O'Hara

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Robots, Artificial Intelligence, and Service Automation, or RAISA, has become increasingly accessible and affordable for a wider demographic of businesses, including hospitality operations, to implement over the last couple of decades. Especially over the past five years, we’ve seen a significant surge of interest in automating within the service industry and a coupled sense of uneasiness that this technological development would in turn displace the human workers, due to factors such as cost of labor and perceived removal of human error; however, this thesis will posit that automation is most effectively used by augmenting the capabilities of the present workforce. …

Factors Influencing Primate Hair Microbiome Diversity, Catherine Kitrinos

Masters Theses

Primate hair is both a substrate upon which essential social interactions occur and an important host-pathogen interface. As commensal microbes provide important immune functions for their hosts, understanding the microbial diversity in primate hair could provide insight into primate immunity and disease transmission. While studies of human hair and skin microbiomes show differences in microbial communities across body regions, little is known about the nonhuman primate hair microbiome. In this study, we collected hair samples (n=159) from 8 body regions across 12 nonhuman primate species housed at 3 US institutions to examine 1) the diversity and composition of the primate …

Water-Responsive, Peptide-Based Crystals, Roxana Piotrowska

Dissertations, Theses, and Capstone Projects

Water-responsive (WR) materials  that exert significant forces in response to changing hydration levels are receiving growing interest due to their potential applications, including use as actuators for energy harvesting devices, artificial muscles, and soft robotics. Reported examples include biological and synthetic materials with abilities to efficiently convert the chemical potential of water into mechanical actuations. However, these systems are typically complex, and consequently, their WR mechanisms are not well-understood thus preventing rational design and optimization. This thesis demonstrates the design and development of WR peptide crystals that mimic and enhance understanding of natural WR systems. The peptide crystals, with intrinsic …