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Articles 1171 - 1200 of 4479

Full-Text Articles in Neuroscience and Neurobiology

Modelling Short-Latency Disparity-Vergence Eye Movements Under Dichoptic Unbalanced Stimulation, Agostino Gibaldi, Guido Maiello, Peter J. Bex, Silvio P. Sabatini May 2016

Modelling Short-Latency Disparity-Vergence Eye Movements Under Dichoptic Unbalanced Stimulation, Agostino Gibaldi, Guido Maiello, Peter J. Bex, Silvio P. Sabatini

MODVIS Workshop

Vergence eye movements align the optical axes of our two eyes onto an object of interest, thus facilitating the binocular summation of the images projected onto the left and the right retinae into a single percept. Both the computational substrate and the functional behaviour of binocular vergence eye movements have been the topic of in depth investigation. Here, we attempt to bring together what is known about computation and function of vergence mechanism. To this aim, we evaluated of a biologically inspired model of horizontal and vertical vergence control, based on a network of V1 simple and complex cells. The ...


Learning Object Representations For Modeling Attention In Real World Scenes, Alex Schwarz, Frederik Beuth, Fred H. Hamker May 2016

Learning Object Representations For Modeling Attention In Real World Scenes, Alex Schwarz, Frederik Beuth, Fred H. Hamker

MODVIS Workshop

Models of visual attention have been rarely used in real world tasks as they have been typically developed for psychophysical setups using simple stimuli. Thus, the question remains how objects must be represented to allow such models an operation in real world scenarios. We have previously presented an attention model capable of operating on real-world scenes (Beuth, F., and Hamker, F. H. 2015, NCNC, which is a successor of Hamker, F. H., 2005, Cerebral Cortex), and show here how its object representations have been learned. We have used a learning rule based on temporal continuity (Földiák, P., 1991, Neural Computation ...


Tau And Aβ Imaging, Csf Measures, And Cognition In Alzheimer's Disease, Matthew R. Brier, Brian Gordon, Karl Friedrichsen, John E. Mccarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J. Cairns, David M. Holtzman, Anne M. Fagan, John C. Morris, Tammie L.S. Benzinger, Beau M. Ances May 2016

Tau And Aβ Imaging, Csf Measures, And Cognition In Alzheimer's Disease, Matthew R. Brier, Brian Gordon, Karl Friedrichsen, John E. Mccarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J. Cairns, David M. Holtzman, Anne M. Fagan, John C. Morris, Tammie L.S. Benzinger, Beau M. Ances

Mathematics Faculty Publications

Alzheimer’s disease (AD) is characterized by two molecular pathologies: cerebral β-amyloidosis in the form of β-amyloid (Aβ) plaques and tauopathy in the form of neurofibrillary tangles, neuritic plaques, and neuropil threads. Until recently, only Aβ could be studied in humans using positron emission tomography (PET) imaging owing to a lack of tau PET imaging agents. Clinical pathological studies have linked tau pathology closely to the onset and progression of cognitive symptoms in patients with AD. We report PET imaging of tau and Aβ in a cohort of cognitively normal older adults and those with mild AD. Multivariate analyses identified ...


Soluble Rage Treatment Delays Progression Of Amyotrophic Lateral Sclerosis In Sod1 Mice, Judyta K. Juranek, Gurdip K. Daffu, Matthew S. Geddis, Huilin Li, Rosa Rosario, Benjamin J. Kaplan, Lauren Kelly, Ann Marie Schmidt May 2016

Soluble Rage Treatment Delays Progression Of Amyotrophic Lateral Sclerosis In Sod1 Mice, Judyta K. Juranek, Gurdip K. Daffu, Matthew S. Geddis, Huilin Li, Rosa Rosario, Benjamin J. Kaplan, Lauren Kelly, Ann Marie Schmidt

Publications and Research

The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by progressive muscle weakness and spasticity, remains largely unknown. Approximately 5–10% of cases are familial, and of those, 15–20% are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). Mutations of the SOD1 gene interrupt cellular homeostasis and contribute to cellular toxicity evoked by the presence of altered SOD1, along with other toxic species, such as advanced glycation end products (AGEs). AGEs trigger activation of their chief cell surface receptor, RAGE (receptor for advanced glycation end products), and induce RAGE-dependent cellular stress ...


Expression And Function Of Inflammation-Associated Micrornas In Traumatic Brain Injury, Emily Harrison May 2016

Expression And Function Of Inflammation-Associated Micrornas In Traumatic Brain Injury, Emily Harrison

Theses & Dissertations

MicroRNAs (miRNAs) are important regulators of gene expression. Many neurological diseases, including traumatic brain injury alter expression of miRNAs in the brain. However, the function of these molecules in the context of TBI is largely unknown. Here we report multiple potential roles for miRNAs in TBI, some of which extend beyond the traditional model of post-transcriptional regulation, highlighting that these RNA molecules may have broader implications for the neurobiology of disease. We found that miR-155 plays an essential role in interferon expression after CCI and that miR-155 contributes to TBI induced anxiety, potentially through regulation of interferons. Expression of miR-155 ...


The Tnfα-Transgenic Rat: Hippocampal Synaptic Integrity, Cognition, Function, And Post-Ischemic Cell Loss, L. Creed Pettigrew, Richard J. Kryscio, Christopher M. Norris May 2016

The Tnfα-Transgenic Rat: Hippocampal Synaptic Integrity, Cognition, Function, And Post-Ischemic Cell Loss, L. Creed Pettigrew, Richard J. Kryscio, Christopher M. Norris

Sanders-Brown Center on Aging Faculty Publications

The cytokine, tumor necrosis factor α (TNFα), is a key regulator of neuroinflammation linked to numerous neurodegenerative conditions and diseases. The present study used transgenic rats that overexpress a murine TNFα gene, under the control of its own promoter, to investigate the impact of chronically elevated TNFα on hippocampal synaptic function. Neuronal viability and cognitive recovery in TNFα Tg rats were also determined following an ischemic insult arising from reversible middle cerebral artery occlusion (MCAO). Basal CA3-CA1 synaptic strength, recorded in acute brain slices, was not significantly different between eight-week-old TNFα Tg rats and non-Tg rats. In contrast, slices from ...


Regardless Of Genotype, Offspring Of Vip-Deficient Female Mice Exhibit Developmental Delays And Deficits In Social Behavior., Hewlet Mcfarlane May 2016

Regardless Of Genotype, Offspring Of Vip-Deficient Female Mice Exhibit Developmental Delays And Deficits In Social Behavior., Hewlet Mcfarlane

Hewlet McFarlane

Pharmacological studies indicate that vasoactive intestinal peptide (VIP) may be necessary for normal embryonic development in the mouse. For example, VIP antagonist treatment before embryonic day 11 resulted in developmental delays, growth restriction, modified adult brain chemistry and reduced social behavior. Here, developmental milestones, growth, and social behaviors of neonates of VIP-deficient mothers (VIP +/-) mated to VIP +/- males were compared with the offspring of wild type mothers (VIP +/+) mated to VIP +/+ and +/- males, to assess the contributions of both maternal and offspring VIP genotype. Regardless of their own genotype, all offsprings of VIP-deficient mothers exhibited developmental delays. No delays were ...


Social Approach Behaviors Are Similar On Conventional Versus Reverse Lighting Cycles, And In Replications Across Cohorts, In Btbr T+ Tf/J, C57bl/6j, And Vasopressin Receptor 1b Mutant Mice, Hewlet Mcfarlane May 2016

Social Approach Behaviors Are Similar On Conventional Versus Reverse Lighting Cycles, And In Replications Across Cohorts, In Btbr T+ Tf/J, C57bl/6j, And Vasopressin Receptor 1b Mutant Mice, Hewlet Mcfarlane

Hewlet McFarlane

Mice are a nocturnal species, whose social behaviors occur primarily during the dark phase of the circadian cycle. However, laboratory rodents are frequently tested during their light phase, for practical reasons. We investigated the question of whether light phase testing presents a methodological pitfall for investigating mouse social approach behaviors. Three lines of mice were systematically compared. One cohort of each line was raised in a conventional lighting schedule and tested during the light phase, under white light illumination; another cohort was raised in a reverse lighting schedule and tested during their dark phase, under dim red light. Male C57BL ...


Reduced Ultrasonic Vocalizations In Vasopressin 1b Knockout Mice., Hewlet Mcfarlane May 2016

Reduced Ultrasonic Vocalizations In Vasopressin 1b Knockout Mice., Hewlet Mcfarlane

Hewlet McFarlane

The neuropeptides oxytocin and vasopressin have been implicated in rodent social and affiliative behaviors, including social bonding, parental care, social recognition, social memory, vocalizations, territoriality, and aggression, as well as components of human social behaviors and the etiology of autism. Previous investigations of mice with various manipulations of the oxytocin and vasopressin systems reported unusual levels of ultrasonic vocalizations in social settings. We employed a vasopressin 1b receptor (Avpr1b) knockout mouse to evaluate the role of the vasopressin 1b receptor subtype in the emission of ultrasonic vocalizations in adult and infant mice. Avpr1b null mutant female mice emitted fewer ultrasonic ...


The Relationship Between Time Of Day, Mood, And Electroencephalography (Eeg) Asymmetry, Morgan Tantillo May 2016

The Relationship Between Time Of Day, Mood, And Electroencephalography (Eeg) Asymmetry, Morgan Tantillo

Honors Projects

Previous researchers have had success in finding a correlation between exercise and an increase in positive mood. Researchers have also found a correlation between time of day and mood. The current study will explore the relationship between time of day, mood, and electroencephalography (EEG) asymmetry. The study utilized a convenient sample of ten undergraduate students at Bowling Green State University. Participants had baseline EEG recordings taken, and then participated in moderate exercise, followed by another EEG recording. Participants’ mood was assessed through a self-reported mood questionnaire before the condition as well as immediately after. Due to multiple statistical tests, the ...


Anatomical Markers For Elevated Cognition In Dinosaurs, Thomas Gaetano May 2016

Anatomical Markers For Elevated Cognition In Dinosaurs, Thomas Gaetano

Honors Projects

Much research has been conducted on brain evolution within Dinosauria. Dinosaurs were originally believed to be incapable of any advanced cognitive abilities beyond the level observed in modern reptiles. This is likely true for many dinosaurs, but recent discoveries suggest that the non-avian maniraptor dinosaurs shared many physical characteristics with their bird descendants, including body feathers and neural adaptations for flight. By studying cranial endocasts (the braincase of fossilized skulls) using computed tomography (CT), paleontologists are beginning to understand the neural changes that took place across the dinosaur-bird transition. Most of these studies are focused on the development of flight ...


Acth Prevents Deficits In Fear Extinction Associated With Early Life Seizures, Andrew T. Massey, David K. Lerner, Gregory L. Holmes, Rod C. Scott, Amanda Hernan May 2016

Acth Prevents Deficits In Fear Extinction Associated With Early Life Seizures, Andrew T. Massey, David K. Lerner, Gregory L. Holmes, Rod C. Scott, Amanda Hernan

Open Dartmouth: Faculty Open Access Articles

Objective: Early life seizures (ELS) are often associated with cognitive and psychiatric comorbidities that are detrimental to quality of life. In a rat model of ELS, we explored long-term cognitive outcomes in adult rats. Using ACTH, an endogeneous HPA-axis hormone given to children with severe epilepsy, we sought to prevent cognitive deficits. Through comparisons with dexamethasone, we sought to dissociate the corticosteroid effects of ACTH from other potential mechanisms of action.

Results: Although rats with a history of ELS were able to acquire a conditioned fear learning paradigm and controls, these rats had significant deficits in their ability to extinguish ...


Eye Movement Effects In Simulated Object Recognition Memory Impairment, Dmitriy Kazakov May 2016

Eye Movement Effects In Simulated Object Recognition Memory Impairment, Dmitriy Kazakov

Theses and Dissertations

Malingering is the purposeful fabrication of symptoms for secondary gain. Memory problems are the most reported symptom, and object recognition tests are often used in clinical settings to evaluate these claims. Past research has shown that eye movements can indirectly index memory, in that greater viewing is directed at studied stimuli 500-750 ms after display onset. The present study evaluated eye movements as a potential method of detecting feigned memory impairment. Forty-eight participants, half simulators, studied standardized images and took a memory test. Several levels of analysis were used to detect broad trends and brief effects. Simulators performed significantly worse ...


Foot Kinematics And Neuromuscular Preactivation In Habitual Forefoot And Rearfoot Runners, Rhiannon Seneli May 2016

Foot Kinematics And Neuromuscular Preactivation In Habitual Forefoot And Rearfoot Runners, Rhiannon Seneli

Theses and Dissertations

As the rate of running related injuries has failed to decline despite advances in footwear, many researchers have begun focusing on different foot strike patterns possible contribution to injury risk. While many studies have focused on the differences between RFS and FFS running, few have investigated kinematic differences within the distal foot in habitual RFS and FFS runners and have failed to consider mechanical and neuromuscular changes due to fatigue. The purpose of this study, therefore, was to investigate foot kinematics and neuromuscular differences between RFS and FFS runners at the beginning and end of an exhaustive run. Fifteen habitual ...


Gap Junction Communication In Memory Retrieval And Extinction Of Cocaine Seeking, Michael Fitzgerald May 2016

Gap Junction Communication In Memory Retrieval And Extinction Of Cocaine Seeking, Michael Fitzgerald

Theses and Dissertations

Blocking drug-associated memory retrieval or enhancing extinction of drug-seeking behavior are two strategies that could limit relapse in drug addicts. The loci of retrieval and extinction memory processes include the prelimbic medial prefrontal cortex and the infralimbic medial prefrontal cortex, respectively. The neurochemical and synaptic mechanisms underlying drug-related behavior have received considerable attention, but extrasynaptic mechanisms are relatively unexplored. One form of cellular communication, gap junction communication, may play a role in drug-related learning and memory. Gap junction communication between neurons and astrocytes provide a cytoplasmic continuity between connected cells and both neuronal and astrocytic gap junction communication have been ...


Stretch Feedback In The Lobster Heart: Experimental And Computational Analysis, Katelyn J. Suchyta May 2016

Stretch Feedback In The Lobster Heart: Experimental And Computational Analysis, Katelyn J. Suchyta

Honors Projects

No abstract provided.


Ethical Challenges In Preclinical Alzheimer's Disease Observational Studies And Trials: Results Of The Barcelona Summit, Jose L. Molinuevo, Jordi Cami, Xavier Carne, Maria C. Carrillo, Jean Georges, Maria B. Isaac, Zaven Khachaturian, Scott Y. H. Kim, John C. Morris, Florence Pasquier, Craig Ritchie, Reisa Sperling, Jason Karlawish May 2016

Ethical Challenges In Preclinical Alzheimer's Disease Observational Studies And Trials: Results Of The Barcelona Summit, Jose L. Molinuevo, Jordi Cami, Xavier Carne, Maria C. Carrillo, Jean Georges, Maria B. Isaac, Zaven Khachaturian, Scott Y. H. Kim, John C. Morris, Florence Pasquier, Craig Ritchie, Reisa Sperling, Jason Karlawish

Neuroethics Publications

Alzheimer's disease (AD) is among the most significant health care burdens. Disappointing results from clinical trials in late-stage AD persons combined with hopeful results from trials in persons with early-stage suggest that research in the preclinical stage of AD is necessary to define an optimal therapeutic success window. We review the justification for conducting trials in the preclinical stage and highlight novel ethical challenges that arise and are related to determining appropriate risk-benefit ratios and disclosing individuals' biomarker status. We propose that to conduct clinical trials with these participants, we need to improve public understanding of AD using unified ...


Cannabis Use And Affective Processing: A Brain Structure Analysis, Kristin E. Maple May 2016

Cannabis Use And Affective Processing: A Brain Structure Analysis, Kristin E. Maple

Theses and Dissertations

Cannabis is the most commonly used illicit drug amongst adolescents and young adults in the United States. Previously, cannabis and its components have been associated with differences in affective processing and neural functioning. Participants (ages 16-25) were cannabis users and non-users excluded for psychiatric disorders, major medical conditions, and excessive other drug use. A series of multiple regressions examined whether past year cannabis use and cannabis x gender predicted measures of emotional face processing (using the PennCNP affective battery) as well as volumes in bilateral prefrontal, temporal, limbic, and cerebellar regions, as well as frontolimbic white matter tracts. Subsequently, Pearson ...


Effect Of Zymosan-Induced Peritonitis On The Expression Of Substance P In Primary Sensory Neurons And Spinal Nerve Processes, Michael G. Armstrong May 2016

Effect Of Zymosan-Induced Peritonitis On The Expression Of Substance P In Primary Sensory Neurons And Spinal Nerve Processes, Michael G. Armstrong

Undergraduate Honors Theses

Macrophages and other cells of the innate immune system recognize foreign particles that could be potentially dangerous and respond by initiating an inflammatory response. The biologically active chemical mediators of this response called pro-inflammatory cytokines are produced in various myeloid derived immune cells and can affect other cells of the body. Interleukin-1β, a pro-inflammatory cytokine, has been shown to have direct effects on dorsal root ganglion (DRG) cell bodies including the upregulation and direct release of a nociceptive neurotransmitter called substance P (SP). Using a zymosan-induced model of systemic inflammation, we hypothesized that murine DRG neurons and the nerve processes ...


Exploring The Effect Of Novel Small Molecules On Oligodendrocyte Precursor Proliferation, Sagune Sakya May 2016

Exploring The Effect Of Novel Small Molecules On Oligodendrocyte Precursor Proliferation, Sagune Sakya

University Scholar Projects

Gliomas, a type of brain tumor, can be difficult to treat and have a poor survival rate. One pathway that leads to glioma formation is excessive signaling by platelet derived growth factors (PDGF) through PDGF receptor α (PDGFRα). Through this research, I found that novel compounds that downregulate PDGFRα decrease proliferation of Oli-neu cells, an oligodendrocyte precursor cell model, and identified signaling pathways through which these compounds may exert their effect. Further investigation may identify targets for development of glioma treatments.


Development Of Vip-Sst Interneuron Associations In Mouse Neocortex And Entorhinal Cortex, Aayushi A. Mehta May 2016

Development Of Vip-Sst Interneuron Associations In Mouse Neocortex And Entorhinal Cortex, Aayushi A. Mehta

Honors Scholar Theses

Cortical networks depend upon inhibition through the neurotransmitter GABA to control and coordinate specific spatiotemporal circuit patterns, underlying the exquisite complexity of neural signaling. Disinhibition, a form of inhibition where inhibitory neurons inhibit other inhibitory cells, further aids in amplifying local neural processing in a selective, organized manner. A subset of GABAergic interneurons, vasoactive intestinal peptide-expressing (VIP) cells, preferentially inhibit somatostatin interneurons, which provide inhibitory input onto pyramidal cells, thus creating an archetypal circuit illustrating disinhibition in the cortex. The aim of this anatomical study was to investigate variations in GABAergic VIP synapses onto somatostatin-expressing inhibitory interneurons in mice at ...


Histological Verification Of Electrode Placement In Single Unit Recorded Rats, Dana Lew May 2016

Histological Verification Of Electrode Placement In Single Unit Recorded Rats, Dana Lew

Honors Scholar Theses

The hippocampus is a region of the brain which plays a major role in encoding spatial and episodic memory. The hippocampus is divided in to two main subregions, dorsal and ventral. These subregions are connected, but their functional organization remains widely unknown. Place cells are cells of the hippocampus which fire in a specific spatial area and help create a mental map of our surroundings. Place cells have been seen to remain constant during slight fluctuations in surroundings, but completely remap in response to large fluctuations in the environment. There is little known about the relatively few place cells in ...


Investigation Of Neural Mechanisms Of Grip Relaxation, Binal Motawar May 2016

Investigation Of Neural Mechanisms Of Grip Relaxation, Binal Motawar

Theses and Dissertations

Neural mechanisms for grip relaxation are relatively unknown and understudied, as compared to mechanisms for grip initiation. Yet, termination of motor activity is as important as initiation in daily function. This knowledge gap presents incomplete understanding of neural control of hand function and its impairment with aging and neurologic disorders. The purpose of this dissertation was to identify and examine neural mechanisms of grip relaxation in healthy young adults, with aging, and in chronic stroke survivors. A series of experiments in healthy young adults showed that the relaxation from a maximum power grip was mediated by increase in the short-interval ...


Child Massage Integrated Therapy: A Preliminary Intervention Manual For Psychological Trauma Treatment, Sylvie P. Demers May 2016

Child Massage Integrated Therapy: A Preliminary Intervention Manual For Psychological Trauma Treatment, Sylvie P. Demers

Doctorate in Social Work (DSW) Dissertations

This dissertation introduces an original preliminary treatment manual as a guide for mental health providers interested in adding a research-informed massage therapy component to traditional child trauma psychotherapy.Child Massage Integrated Therapy (CMIT) offers a standardized protocol to support the implementation of a replicable treatment modality that fosters critical somatic resources for traumatized children within real-world settings. The multidisciplinary field of interpersonal neurobiology, including attachment and polyvagal theories, as well as the concept of interoceptive awareness, are the theoretical constructs informing the proposed model of care. A review of the research literature recognizing massage therapy's role in creating a ...


Cognitive Functioning Of Drumming And Rhythm Therapy For Neurological Disorders, Logan James Deyo May 2016

Cognitive Functioning Of Drumming And Rhythm Therapy For Neurological Disorders, Logan James Deyo

University of Tennessee Honors Thesis Projects

No abstract provided.


Network Dynamics Of Visual Object Recognition, Mehmet C. Kadipasaoglu May 2016

Network Dynamics Of Visual Object Recognition, Mehmet C. Kadipasaoglu

UT GSBS Dissertations and Theses (Open Access)

Visual object recognition is the principal mechanism by which humans and many animals interpret their surroundings. Despite the complexity of neural computation required, object recognition is achieved with such rapidity and accuracy that it appears to us almost effortless. Extensive human and non-human primate research has identified putative category-selective regions within higher-level visual cortex, which are thought to mediate object recognition. Despite decades of study, however, the functional organization and network dynamics within these regions remain poorly understood, due to a lack of appropriate animal models as well as the spatiotemporal limitations of current non-invasive human neuroimaging techniques (e.g ...


Building Object Representations: Mechanisms Of Perceptual Learning In Human Visual Cortex, Stephanie M. Long May 2016

Building Object Representations: Mechanisms Of Perceptual Learning In Human Visual Cortex, Stephanie M. Long

Psychological Science Undergraduate Honors Theses

Extensive literature in the cognitive neurosciences has been dedicated to understanding the neural processes involved in object category learning. However, much remains to be learned regarding the mechanisms by which high-level visual patterns are extracted from a crowded visual scene, segregated into discrete object categories, and represented in the cortical visual hierarchy. Here, we used event-related potentials (ERPs) to investigate the neural underpinnings of visual object category extraction in a cluttered visual environment. Electroencephalography (EEG) was continuously recorded while subjects were given a hybrid of an object category learning and visual search task. In this hybrid task, a peripheral array ...


Functional Role Of Each Component In Gamma Secretase Complex, Chen Hu May 2016

Functional Role Of Each Component In Gamma Secretase Complex, Chen Hu

Doctoral Dissertations

Amyloid hypothesis is widely accepted as the centerpiece of Alzheimer’s disease (AD) pathogenesis. It is believed that the accumulation of amyloid beta (Ab) is the major deterministic factor of AD and the most important causative factor is the ratio of Ab42/Ab40. Gamma(g)-secretase defines the length of Ab and is composed of at least four subunits: presenilins (PS1 or PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (Pen-2). They have been reported to have different roles in g-secretase. For example, PS were believed as the catalytic components in g-secretase; NCT was recognized as a ...


Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou May 2016

Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou

Engineering and Applied Science Theses & Dissertations

Stroke is the most common cause of long-term severe disability and the motor system that is most commonly affected in stroke. One of the mechanisms that underlies recovery of motor deficits is reorganization or remapping of functional representations around the motor cortex. This mechanism has been shown in monkeys, but results in human subjects have been variable. In this thesis, I used a database that includes longitudinal behavioral and multimodal imaging data in both stroke patients and healthy controls for two research projects. Firstly, I improved an automatic lesion segmentation method to aid in the identification of the location and ...


Assessing Clinical Significance Of The Immediate Post-Concussion Assessment And Cognitive Testing Battery When Comparing Adjusted And Unadjusted Rci Methods For Different Ranges Of Baseline Scores, Ashley N. Figaro May 2016

Assessing Clinical Significance Of The Immediate Post-Concussion Assessment And Cognitive Testing Battery When Comparing Adjusted And Unadjusted Rci Methods For Different Ranges Of Baseline Scores, Ashley N. Figaro

UNLV Theses, Dissertations, Professional Papers, and Capstones

The growing concern revolving around the dangers of sports-related concussions have led to the most recent implementation of neurocognitive (NC) test batteries as a means to objectively determine the presence of a cognitive defect. Whereas any other sports-related injury can be diagnosed with tools such as an x-ray or MRI, a concussion represents a metabolic disturbance that cannot be identified by these diagnostic tools. Many neurocognitive test batteries employ statistical techniques to derive cut off scores in order to represent significant or insignificant changes as compared to individual baseline scores, or pre-established normative values. If an individuals’ post-injury score exceeds ...