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Articles 1171 - 1200 of 3581

Full-Text Articles in Neuroscience and Neurobiology

Aqueductal Narrowing, Congenital And Acquired: A Critical Review Of The Histologic Criteria, David Drachman, Edward Richardson Dec 2014

Aqueductal Narrowing, Congenital And Acquired: A Critical Review Of The Histologic Criteria, David Drachman, Edward Richardson

David A. Drachman

No abstract provided.


An Approach To The Neurology Of Aging, David Drachman Dec 2014

An Approach To The Neurology Of Aging, David Drachman

David A. Drachman

No abstract provided.


Familial And Sporadic Alzheimer's Disease: Neuropathology Cannot Exclude A Final Common Pathway, Carol Lippa, Ann Saunders, Thomas Smith, Joan Swearer, David Drachman, Bernardino Ghetti, Linda Nee, D. Pulaski-Salo, Dennis Dickson, Yves Robitaille, C. Bergeron, Barbara Crain, Merrill Benson, Martin Farlow, Bradley Hyman, Peter St. George-Hyslop, Allen Roses, Daniel Pollen Dec 2014

Familial And Sporadic Alzheimer's Disease: Neuropathology Cannot Exclude A Final Common Pathway, Carol Lippa, Ann Saunders, Thomas Smith, Joan Swearer, David Drachman, Bernardino Ghetti, Linda Nee, D. Pulaski-Salo, Dennis Dickson, Yves Robitaille, C. Bergeron, Barbara Crain, Merrill Benson, Martin Farlow, Bradley Hyman, Peter St. George-Hyslop, Allen Roses, Daniel Pollen

David A. Drachman

Whether all etiologic forms of Alzheimer's disease (AD) share a final common pathway is a major issue. We determined the severity and regional distribution of neuronal loss, amyloid plaques, neuritic plaques (NPs), and neurofibrillary tangles (NFTs), and calculated the ratio of neuronal loss to NPs and NFTs in brains of 19 familial AD (FAD) patients with linkage to chromosome 14, six AD patients with mutations of chromosome 21 (codon 717 of the beta-amyloid percursor protein gene), and 11 sporadic AD (SAD) patients. There was no difference in the pattern of distribution of the various pathologic features or in the ...


If We Live Long Enough, Will We All Be Demented, David Drachman Dec 2014

If We Live Long Enough, Will We All Be Demented, David Drachman

David A. Drachman

No abstract provided.


The Treatment Of Alzheimer's Disease: Where Have We Been, And Where Are We Going, David Drachman Dec 2014

The Treatment Of Alzheimer's Disease: Where Have We Been, And Where Are We Going, David Drachman

David A. Drachman

No abstract provided.


Alzheimer's Disease And Aging: Effects On Perforant Pathway Perikarya And Synapses, Carol Lippa, James Hamos, D. Pulaski-Salo, Louis Degennaro, David Drachman Dec 2014

Alzheimer's Disease And Aging: Effects On Perforant Pathway Perikarya And Synapses, Carol Lippa, James Hamos, D. Pulaski-Salo, Louis Degennaro, David Drachman

David A. Drachman

The hippocampal perforant pathway originates in the entorhinal cortex (ERC) and terminates in the outer molecular layer of the dentate gyrus (DG). To compare the effects of normal aging and Alzheimer's disease (AD) on the elements of the perforant pathway, we compared relative perikaryal numbers (determined by counting cell bodies and estimating volumes) in layer II of the ERC with synaptic quantities (estimated from immunoreactivity for the synaptic terminal protein synapsin I and DG volume) in the molecular layer of the DG. The brains of 5 young and 9 elderly cognitively normal individuals, and of 9 AD patients were ...


Neurological Evaluation In The Elderly Patient, David Drachman, Randall Long, Joan Swearer Dec 2014

Neurological Evaluation In The Elderly Patient, David Drachman, Randall Long, Joan Swearer

David A. Drachman

No abstract provided.


Dementia, Butterfly Ballots, And Voter Competence, Victor Henderson, David Drachman Dec 2014

Dementia, Butterfly Ballots, And Voter Competence, Victor Henderson, David Drachman

David A. Drachman

No abstract provided.


How Normal Aging Relates To Dementia: A Critique And Classification, David Drachman Dec 2014

How Normal Aging Relates To Dementia: A Critique And Classification, David Drachman

David A. Drachman

No abstract provided.


Commentary On "A Roadmap For The Prevention Of Dementia: The Inaugural Leon Thal Symposium." Prevention Of Dementia: Roadmap Or Maintenance Manual, David Drachman Dec 2014

Commentary On "A Roadmap For The Prevention Of Dementia: The Inaugural Leon Thal Symposium." Prevention Of Dementia: Roadmap Or Maintenance Manual, David Drachman

David A. Drachman

No abstract provided.


The Genetic Defect Causing Familial Alzheimer's Disease Maps On Chromosome 21, Peter St.George-Hyslop, Rudolph Tanzi, Ronald Polinsky, Jonathan Haines, Linda Nee, Paul Watkins, Richard Myers, Robert Feldman, Daniel Pollen, David Drachman Dec 2014

The Genetic Defect Causing Familial Alzheimer's Disease Maps On Chromosome 21, Peter St.George-Hyslop, Rudolph Tanzi, Ronald Polinsky, Jonathan Haines, Linda Nee, Paul Watkins, Richard Myers, Robert Feldman, Daniel Pollen, David Drachman

David A. Drachman

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in which Alzheimer's disease is caused by an autosomal dominant gene defect. The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21. The localization on chromosome 21 provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome. Isolation and characterization of the gene at this locus may yield new insights into the nature of the defect causing familial Alzheimer's disease and possibly, into the etiology ...


New Criteria For The Diagnosis Of Vascular Dementia: Do We Know Enough Yet, David Drachman Dec 2014

New Criteria For The Diagnosis Of Vascular Dementia: Do We Know Enough Yet, David Drachman

David A. Drachman

No abstract provided.


The Remote Myopathy Of Trichinosis, David Drachman, Ture Tuncbay Dec 2014

The Remote Myopathy Of Trichinosis, David Drachman, Ture Tuncbay

David A. Drachman

No abstract provided.


Risk Factors For Seizure-Related Motor Vehicle Crashes In Patients With Epilepsy, David Drachman Dec 2014

Risk Factors For Seizure-Related Motor Vehicle Crashes In Patients With Epilepsy, David Drachman

David A. Drachman

No abstract provided.


Genetic Linkage Analysis Of Familial Alzheimer's Disease, J. Gusella, David Drachman Dec 2014

Genetic Linkage Analysis Of Familial Alzheimer's Disease, J. Gusella, David Drachman

David A. Drachman

No abstract provided.


A 69-Year-Old Man With Chronic Dizziness, David Drachman Dec 2014

A 69-Year-Old Man With Chronic Dizziness, David Drachman

David A. Drachman

No abstract provided.


Motor Neuron Disease And Paraproteinemia, Stacy Rudnicki, David Chad, David Drachman, Thomas Smith, Ursula Anwer, N. Levitan Dec 2014

Motor Neuron Disease And Paraproteinemia, Stacy Rudnicki, David Chad, David Drachman, Thomas Smith, Ursula Anwer, N. Levitan

David A. Drachman

We studied two patients with motor neuron disease and paraproteinemia. One had amyotrophic lateral sclerosis (ALS) and IgG lambda monoclonal gammopathy. The second had slowly progressive muscular atrophy and an IgM kappa paraprotein, followed by a biclonal gammopathy when an IgA kappa paraprotein appeared. Treatment with immunosuppressive agents and plasmapheresis lowered the serum concentration of the paraproteins. The ALS syndrome progressed despite therapy. The other patient improved, was stable for several years, but then deteriorated despite continued therapy.


Book Review: Biology Of Memory, David Drachman Dec 2014

Book Review: Biology Of Memory, David Drachman

David A. Drachman

Book review of Biology of memory. K.H. Pribram and D.E. Broadbent (Editors). Academic, New York, 1970, 323 p.


Human Memory And The Cholinergic System. A Relationship To Aging, David Drachman, Janet Leavitt Dec 2014

Human Memory And The Cholinergic System. A Relationship To Aging, David Drachman, Janet Leavitt

David A. Drachman

No abstract provided.


The Senile Patient, David Drachman Dec 2014

The Senile Patient, David Drachman

David A. Drachman

No abstract provided.


Who May Drive? Who May Not? Who Shall Decide, David Drachman Dec 2014

Who May Drive? Who May Not? Who Shall Decide, David Drachman

David A. Drachman

No abstract provided.


Apolipoprotein E Epsilon 4 Allele And The Lifetime Risk Of Alzheimer's Disease. What Physicians Know, And What They Should Know, Sudha Seshadri, David Drachman, Carol Lippa Dec 2014

Apolipoprotein E Epsilon 4 Allele And The Lifetime Risk Of Alzheimer's Disease. What Physicians Know, And What They Should Know, Sudha Seshadri, David Drachman, Carol Lippa

David A. Drachman

BACKGROUND: Published studies now show a clear association between Alzheimer's disease (AD) and the apolipoprotein E epsilon 4 allele (APOE* epsilon 4). The clinical value of this information to estimate a healthy individual's lifetime risk of AD has not been well delineated. Physicians dealing with AD may not know either the lifetime risk of developing AD or the effect of the APOE genotype on this risk. Because the lifetime risk of AD depends in part on life expectancy, and available figures on APOE are not population based, a computation is necessary to derive risk estimates useful to physicians ...


Caretaker Obstreperous Behavior Rating Scale, Joan Swearer, David Drachman Dec 2014

Caretaker Obstreperous Behavior Rating Scale, Joan Swearer, David Drachman

David A. Drachman

Although Alzheimer's original description of the dementing disorder that bears his name emphasized the prominence of troublesome and disruptive behaviors, a systematic investigation of behavioral disturbances of dementia did not begin in earnest until the 1980s. At that time, as the neuropathologic identity of presenile Alzheimer's disease and late-onset “senile dementia” was recognized, the redefinition of Alzheimer's disease abruptly increased the number of patients diagnosed with this condition. Physicians and other medical personnel working with Alzheimer's disease patients recognized both the importance of abnormal behaviors in this now large patient population and the need to describe ...


Dizziness And Disorders Of Equilibrium--Panel 8, David Drachman, Ronald Apfelbaum, Jerome Posner Dec 2014

Dizziness And Disorders Of Equilibrium--Panel 8, David Drachman, Ronald Apfelbaum, Jerome Posner

David A. Drachman

No abstract provided.


Memory Impairment In The Aged: Storage Versus Retrieval Deficit, David Drachman, Janet Leavitt Dec 2014

Memory Impairment In The Aged: Storage Versus Retrieval Deficit, David Drachman, Janet Leavitt

David A. Drachman

No abstract provided.


Vascular Amyloid Deposition In Alzheimer's Disease. Neither Necessary Nor Sufficient For The Local Formation Of Plaques Or Tangles, Carol Lippa, James Hamos, Thomas Smith, Donna Pulaski-Salo, David Drachman Dec 2014

Vascular Amyloid Deposition In Alzheimer's Disease. Neither Necessary Nor Sufficient For The Local Formation Of Plaques Or Tangles, Carol Lippa, James Hamos, Thomas Smith, Donna Pulaski-Salo, David Drachman

David A. Drachman

OBJECTIVE--To determine the relationship between vascular beta-amyloid (beta A4) and senile plaques (SPs) and neurofibrillary tangles (NFTs). DESIGN--We counted vascular amyloid deposition with SP and NFT density in the medial temporal lobe (CA1 plus the subiculum) and the cerebellum. PATIENTS--The brains of seven patients with Alzheimer's disease and of three age-matched nondemented control subjects were studied. RESULTS--In Alzheimer's disease, the density of beta A4-laden blood vessels was significantly higher in the cerebellum than in CA1 plus the subiculum. Conversely, the densities of SPs and NFTs were much greater in the CA1 plus the subiculum than in the cerebellum ...


Aging And Dementia: Insights From The Study Of Anticholinergic Drugs, David Drachman Dec 2014

Aging And Dementia: Insights From The Study Of Anticholinergic Drugs, David Drachman

David A. Drachman

No abstract provided.


Histocompatibility (Hl-A) Factors In Familial Multiple Sclerosis. Is Multiple Sclerosis Susceptibility Inherited Via The Hl-A Chromosome, David Drachman, William Davison, Kamal Mittal Dec 2014

Histocompatibility (Hl-A) Factors In Familial Multiple Sclerosis. Is Multiple Sclerosis Susceptibility Inherited Via The Hl-A Chromosome, David Drachman, William Davison, Kamal Mittal

David A. Drachman

In order to study a possible hereditary factor leading to multiple sclerosis (MS) susceptibility, histocompatibility (HL-A) types were studied in families where two or more first-degree relatives had MS. Neither the inheritance of a particular parental HL-A chromosome, nor the occurrence of any specific HL-A antigens, could be shown to be necessary or sufficient for the development of MS in family members. The distribution of HL-A chromosomes was essentially the same for affected and unaffected family members. An excess of 3,7 haplotype and W21 antigen was demonstrated, both in affected patients and in unaffected family members, in equal proportions ...


The Etiology Of Alzheimer's Disease: The Pathogenesis Of Dementia. The Role Of Neurotoxins, David Drachman, Carol Lippa Dec 2014

The Etiology Of Alzheimer's Disease: The Pathogenesis Of Dementia. The Role Of Neurotoxins, David Drachman, Carol Lippa

David A. Drachman

No abstract provided.


The Pharmacological Basis For Cholinergic Investigation Of Alzheimer's Disease: Evidence And Implications, David Drachman Dec 2014

The Pharmacological Basis For Cholinergic Investigation Of Alzheimer's Disease: Evidence And Implications, David Drachman

David A. Drachman

No abstract provided.