Open Access. Powered by Scholars. Published by Universities.®
Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (121)
- Cognitive Neuroscience (100)
- Social and Behavioral Sciences (100)
- Psychology (79)
- Molecular and Cellular Neuroscience (76)
-
- Behavioral Neurobiology (58)
- Other Neuroscience and Neurobiology (40)
- Biology (37)
- Developmental Neuroscience (34)
- Medical Specialties (33)
- Engineering (32)
- Medical Sciences (31)
- Cognitive Psychology (29)
- Cell and Developmental Biology (28)
- Diseases (28)
- Physiology (28)
- Genetics and Genomics (25)
- Psychiatry and Psychology (25)
- Biochemistry, Biophysics, and Structural Biology (24)
- Physical Sciences and Mathematics (24)
- Systems Neuroscience (24)
- Biomedical Engineering and Bioengineering (21)
- Computational Neuroscience (21)
- Neurosciences (20)
- Kinesiology (18)
- Mental and Social Health (16)
- Nervous System Diseases (16)
- Pharmacology, Toxicology and Environmental Health (15)
- Institution
-
- Western University (51)
- City University of New York (CUNY) (35)
- Washington University in St. Louis (32)
- University of Nevada, Las Vegas (26)
- Kenyon College (20)
-
- University of Kentucky (20)
- University of Wisconsin Milwaukee (12)
- Smith College (11)
- West Virginia University (10)
- Nova Southeastern University (9)
- University of Louisville (9)
- Loyola University Chicago (8)
- University of Connecticut (8)
- University of Massachusetts Amherst (8)
- Wright State University (8)
- Florida International University (7)
- University of Arkansas, Fayetteville (7)
- University of Vermont (7)
- Virginia Commonwealth University (7)
- Aga Khan University (6)
- University of Nebraska - Lincoln (6)
- University of Texas at El Paso (6)
- University of Mississippi (5)
- University of Nebraska Medical Center (5)
- DePauw University (4)
- Florida Institute of Technology (4)
- Illinois State University (4)
- Louisiana State University (4)
- New Jersey Institute of Technology (4)
- The Texas Medical Center Library (4)
- Keyword
-
- FMRI (21)
- Attention (14)
- Neuroscience (14)
- Anxiety (12)
- EEG (12)
-
- Memory (12)
- Cognition (11)
- Dopamine (11)
- Development (10)
- Hippocampus (10)
- Alcohol (8)
- Drosophila (8)
- Neurodegeneration (8)
- Stress (8)
- COVID-19 (7)
- Electrophysiology (7)
- Neuroimaging (7)
- Addiction (6)
- Alzheimer’s disease (6)
- Autism (6)
- Brain (6)
- Concussion (6)
- Epilepsy (6)
- Functional connectivity (6)
- Learning (6)
- Resting-state functional connectivity (6)
- Serotonin (6)
- Alzheimer's Disease (5)
- Amygdala (5)
- Autism Spectrum Disorder (5)
- Publication
-
- Electronic Thesis and Dissertation Repository (41)
- Arts & Sciences Electronic Theses and Dissertations (25)
- Theses and Dissertations (23)
- Dissertations, Theses, and Capstone Projects (21)
- Scientific Kenyon: The Neuroscience Edition (20)
-
- Neuroscience: Faculty Publications (11)
- Honors Theses (10)
- Electronic Theses and Dissertations (9)
- Graduate Theses, Dissertations, and Problem Reports (9)
- Journal for Sports Neuroscience (9)
- Publications and Research (9)
- Dissertations (8)
- School of Medicine Faculty Publications (8)
- Undergraduate Student Research Internships Conference (8)
- FIU Electronic Theses and Dissertations (7)
- Graduate College Dissertations and Theses (7)
- McKelvey School of Engineering Theses & Dissertations (7)
- Neuroscience Faculty Publications (7)
- Open Access Theses & Dissertations (6)
- Undergraduate Honors Theses (6)
- Center for Brain, Biology, and Behavior: Faculty and Staff Publications (5)
- Honors Scholar Theses (5)
- Master's Theses (5)
- Masters Theses (5)
- Theses & Dissertations (5)
- Browse all Theses and Dissertations (4)
- Dissertations & Theses (Open Access) (4)
- Dissertations and Theses (4)
- Doctoral Dissertations (4)
- Graduate Theses and Dissertations (4)
- Publication Type
- File Type
Articles 1 - 30 of 484
Full-Text Articles in Neuroscience and Neurobiology
Valorisation Of The Effects Of Bioactive Compounds Of The Ethanolic Extract Of Ramalina Farinacea (Ramalinaceae) On The Development, Eating And Pupation Behavior Of Drosophila Melanogaster (Diptera: Drosophilidae), Fatma Zohra Saadane, Nour El Imene Boublata, Sarra Habbachi, Abir Bouzar, Waffa Habbachi, Abderachid Slimani, Abdelkrim Tahraoui
Valorisation Of The Effects Of Bioactive Compounds Of The Ethanolic Extract Of Ramalina Farinacea (Ramalinaceae) On The Development, Eating And Pupation Behavior Of Drosophila Melanogaster (Diptera: Drosophilidae), Fatma Zohra Saadane, Nour El Imene Boublata, Sarra Habbachi, Abir Bouzar, Waffa Habbachi, Abderachid Slimani, Abdelkrim Tahraoui
Journal of Bioresource Management
Plants are rich in bioactive chemical secondary metabolites and have proven insecticidal activity by killing or repelling insects. In this work, we aim to evaluate the direct and delayed effects of ethanolic plant extracts on the vinegar fly (Drosophila melanogaster). The treatment was performed by ingestion on second instar larvae (L2) to evaluate the impact of the ethanolic extract on development for 15 days and subsequently on the feeding behavior of the larvae. The results of this study indicate a slowing down of pupal growth until the adult stage, at the three concentrations (0.25 µg/ml, 0.5 µg/ml, 1.5 …
The Benefits Of Astaxanthin To Improve Pain Relief In Patients With Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial, Rizaldy Taslim Pinzon, Mary Rose Angelina Budi Harsana
The Benefits Of Astaxanthin To Improve Pain Relief In Patients With Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial, Rizaldy Taslim Pinzon, Mary Rose Angelina Budi Harsana
Pharmaceutical Sciences and Research
Treatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease. Astaxanthin is a potent antioxidant, anti-inflammatory, and anti-diabetic carotenoid that could be an additional treatment option. We aimed to measure the effectiveness of administering astaxanthin as an additional therapy to improve the impact of pain and discomfort experienced daily by diabetes mellitus patients with painful diabetic neuropathy. We conducted a randomized experimental study with an open label design of 36 patients who had been diagnosed with …
Depression And Behavioral Changes Associated With Social Media Dependency During Covid-19 Pandemic Among University Students In Bangladesh: A Cross- Sectional Study, Sushmita Karmokar, Md. Ashraful Islam, Mohammad Hamid Al Muktadir, Rakibul Hasan, Abu Montakim Tareq, Mohammad Nurul Amin, Talha Bin Emran
Depression And Behavioral Changes Associated With Social Media Dependency During Covid-19 Pandemic Among University Students In Bangladesh: A Cross- Sectional Study, Sushmita Karmokar, Md. Ashraful Islam, Mohammad Hamid Al Muktadir, Rakibul Hasan, Abu Montakim Tareq, Mohammad Nurul Amin, Talha Bin Emran
Makara Journal of Health Research
Background: With its rapid spread, the coronavirus disease 2019 (COVID-19) pandemic had a detrimental effect on students’ psychological well-being, depression, and behavioral changes due to indefinite educational leaves, lockdowns, restricted outdoor activities, and excess use of social media. This study aims to assess the relationship of social media exposure with the psychological well-being, depression, and behavioral changes of Bangladeshi university students.
Methods: A web-based cross-sectional survey was carried out on 530 students from June 17 to July 10, 2020, to evaluate psychological well-being, depression, behavioral changes, and social media exposure via self-reported measures.
Results: The prevalence of …
Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang
Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang
Linguistics Graduate Dissertations
In this dissertation, I seek to construct a model of meaning variation built upon variability in linguistic structure, conceptual structure, and cognitive makeup, and in doing so, exemplify an approach to studying meaning that is both linguistically principled and neuropsychologically grounded. As my test case, I make use of the English lexical item ‘have' by proposing a novel analysis of its meaning based on its well-described variability in English and its embed- ding into crosslinguistically consistent patterns of variation and change.
I support this analysis by investigating its real-time comprehension patterns through behavioral, electropsychophysiological, and hemodynamic brain data, thereby incorporating …
Affective Computing For Late-Life Mood And Cognitive Disorders, Erin Smith, Eric A. Storch, Ipsit Vahia, Stephen T.C. Wong, Helen Lavretsky, Jeffrey L. Cummings, Harris A. Eyre
Affective Computing For Late-Life Mood And Cognitive Disorders, Erin Smith, Eric A. Storch, Ipsit Vahia, Stephen T.C. Wong, Helen Lavretsky, Jeffrey L. Cummings, Harris A. Eyre
Brain Health Faculty Publications
Affective computing (also referred to as artificial emotion intelligence or emotion AI) is the study and development of systems and devices that can recognize, interpret, process, and simulate emotion or other affective phenomena. With the rapid growth in the aging population around the world, affective computing has immense potential to benefit the treatment and care of late-life mood and cognitive disorders. For late-life depression, affective computing ranging from vocal biomarkers to facial expressions to social media behavioral analysis can be used to address inadequacies of current screening and diagnostic approaches, mitigate loneliness and isolation, provide more personalized treatment approaches, and …
Probing The Role Of Astrocytes In The Pathology Of Fragile X Syndrome With Human Stem Cells, Baiyan Ren
Probing The Role Of Astrocytes In The Pathology Of Fragile X Syndrome With Human Stem Cells, Baiyan Ren
Theses & Dissertations
Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder related to intellectual disability and the most common monogenic cause of autism spectrum disorder. FXS is mainly caused by an expansion of CGG repeats in the 5’-untranslated region of fragile X mental retardation 1 (FMR1) gene, leading to the loss of expression of fragile X mental retardation protein (FMRP). Astrocytes are the most abundant glial cells in the central nervous system (CNS). Loss of FMRP in astrocytes has been found to contribute to structural and functional synaptic deficits in the Fmr1-KO mouse model. The contribution of human astrocytes, however, to the …
Cgrp-Driven Lateralization Of Pain Modulation By The Central Amygdala, Heather Allen
Cgrp-Driven Lateralization Of Pain Modulation By The Central Amygdala, Heather Allen
Electronic Theses and Dissertations
The central amygdala (CeA) is a bilateral, mid limbic brain region involved in the processing of pain and emotion. Interestingly, the left and right CeA are functionally lateralized in the context of bladder pain, with the left and right CeA having opposing effects on bladder pain-like behavior. However, the specific mechanisms driving these divergent functions are unknown. Nociceptive signals from the bladder are relayed to the CeA via projection neurons in the parabrachial nucleus (PBN) that express high levels of calcitonin gene-related peptide (CGRP). In these studies, we investigated the influence of PBN CGRP signaling in the left and right …
Effects Of Catharanthine On Dopamine Release In The Nucleus Accumbens And Ethanol Consumption, Emily Baldwin
Effects Of Catharanthine On Dopamine Release In The Nucleus Accumbens And Ethanol Consumption, Emily Baldwin
Undergraduate Honors Theses
This thesis discusses the history of catharanthine and related compounds, and their potential anti-addictive properties. Current research is exploring possible mechanisms of these properties. Past studies have found catharanthine has effects on neurons that project to the mesocorticolimbic system, an area implicated in addiction. We have seen that catharanthine decreases evoked dopamine (DA) release but increases basal DA release. This is the first study to investigate catharanthine’s effect on DA transmission in vivo. Using microdialysis, we determined the effect of catharanthine on DA in the nucleus accumbens of the striatum. This study determines the effect of different doses of …
Let There Be Light: Restoring Vision With Optogenetics, Kristin Woodard
Let There Be Light: Restoring Vision With Optogenetics, Kristin Woodard
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Exercise As A Treatment For Cognitive Decline In Older Adults: The Role Of Growth Factors And Inflammatory Cytokines, Joshua A. Titus
Exercise As A Treatment For Cognitive Decline In Older Adults: The Role Of Growth Factors And Inflammatory Cytokines, Joshua A. Titus
Electronic Thesis and Dissertation Repository
The purpose of this thesis was to investigate the effects that exercise modalities have on neurotrophic and inflammatory blood markers and cognitive outcomes in older adults. A systematic review and meta-analysis were completed. The included studies illustrated that most of the literature evaluated the effect of aerobic exercise interventions on systemic concentrations of the blood marker brain-derived neurotrophic factor (BDNF). The review found that aerobic exercise increases BDNF and resistance training increases insulin-like growth factor 1 (IGF-1). Interventions with sex-specific cohorts presented advantages in males for blood marker and cognitive outcomes compared to females. One of three included interventions decreased …
Inter-Subject Correlation While Listening To Minimalist Music: A Study Of Electrophysiological And Behavioral Responses To Steve Reich’S Piano Phase, Tysen Dauer, Duc T. Nguyen, Nick Gang, Jacek P. Dmochowski, Jonathan Berger, Blair Kaneshiro
Inter-Subject Correlation While Listening To Minimalist Music: A Study Of Electrophysiological And Behavioral Responses To Steve Reich’S Piano Phase, Tysen Dauer, Duc T. Nguyen, Nick Gang, Jacek P. Dmochowski, Jonathan Berger, Blair Kaneshiro
Publications and Research
Musical minimalism utilizes the temporal manipulation of restricted collections of rhythmic, melodic, and/or harmonic materials. One example, Steve Reich’s Piano Phase, offers listeners readily audible formal structure with unpredictable events at the local level. For example, pattern recurrences may generate strong expectations which are violated by small temporal and pitch deviations. A hyper-detailed listening strategy prompted by these minute deviations stands in contrast to the type of listening engagement typically cultivated around functional tonal Western music. Recent research has suggested that the inter-subject correlation (ISC) of electroencephalographic (EEG) responses to natural audio-visual stimuli objectively indexes a state of “engagement,” demonstrating …
Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar
Granulins In Norm And Neurodegenerative Pathologies, Anukool Bhopatkar
Dissertations
Granulins (GRNs) are small, cysteine-rich modules produced from the proteolytic cleavage of the precursor protein called progranulin (PGRN). GRNs are present in the form of seven tandem repeats within the precursor and are known to be produced in the extracellular and in lysosomal environments. In physiology, PGRN and GRNs plays pleiotropic roles such as neuronal growth and differentiation, immunomodulation, wound healing. Recent studies have implicated pathological role for PGRN in Alzheimer disease (AD) and frontotemporal dementia (FTD) but specific mechanism(s) remains unclear. However, potential interactions between GRNs and Ab42 and TDP-43 seem like a plausible underlying mechanism. Studies presented here …
Rare And Low Frequency Genomic Variants Impacting Neuronal Functions Modify The Dup7q11.23 Phenotype, Farah Qaiser, Yue Yin, Carolyn B. Mervis, Colleen A. Morris, Bonita P. Klein-Tasman, Elaine Tam, Lucy R. Osborne, Ryan K.C. Yuen
Rare And Low Frequency Genomic Variants Impacting Neuronal Functions Modify The Dup7q11.23 Phenotype, Farah Qaiser, Yue Yin, Carolyn B. Mervis, Colleen A. Morris, Bonita P. Klein-Tasman, Elaine Tam, Lucy R. Osborne, Ryan K.C. Yuen
School of Medicine Faculty Publications
© 2021, The Author(s). Background: 7q11.23 duplication (Dup7) is one of the most frequent recurrent copy number variants (CNVs) in individuals with autism spectrum disorder (ASD), but based on gold-standard assessments, only 19% of Dup7 carriers have ASD, suggesting that additional genetic factors are necessary to manifest the ASD phenotype. To assess the contribution of additional genetic variants to the Dup7 phenotype, we conducted whole-genome sequencing analysis of 20 Dup7 carriers: nine with ASD (Dup7-ASD) and 11 without ASD (Dup7-non-ASD). Results: We identified three rare variants of potential clinical relevance for ASD: a 1q21.1 microdeletion (Dup7-non-ASD) and two deletions which …
Being The Curriculum, Alyssa Hillary Zisk
Being The Curriculum, Alyssa Hillary Zisk
Ought: The Journal of Autistic Culture
This article is a work of creative non-fiction. Part of the work is my reflections on one systemically awkward experience of introducing my neurodivergence, autism, to my classmates in my graduate program in neuroscience. Part of the work engages with theory and neuroscientific/cognitive findings that I either shared during the presentation or encountered since but would have been relevant to the experience. The two parts are intertwined, because life isn't neatly separable.
Interactions Among Sex, Apolipoprotein E Genotype, And 17-Beta Estradiol In A Mouse Model Of Alzheimer's Disease, Lisa Taxier
Interactions Among Sex, Apolipoprotein E Genotype, And 17-Beta Estradiol In A Mouse Model Of Alzheimer's Disease, Lisa Taxier
Theses and Dissertations
Alzheimer’s disease (AD) is the most common form of dementia, yet its cause remains a mystery and no truly effective treatments exist. The high incidence of AD, coupled with its devastating health and economic impacts, highlight the urgent need for continued research into the etiology of this disease (Ernst & Hay, 1994; Rice et al., 1993). Although existing and efficacious treatments for AD are lacking, several risk factors for AD have been identified. One such factor is apolipoprotein E genotype, which is the greatest genetic risk factor for AD (Ertekin-Taner, 2007; van der Flier et al., 2011). Another factor is …
Modulation Of Stress-Induced Behaviors Through Orexinergic Signaling In The Basolateral Amygdala, Jazmine D W Yaeger
Modulation Of Stress-Induced Behaviors Through Orexinergic Signaling In The Basolateral Amygdala, Jazmine D W Yaeger
Dissertations and Theses
Stress initiates behavioral disturbances, which are often seen as symptoms of psychiatric disorders, like post-traumatic stress disorder (PTSD), depression, and anxiety. While stress is involved in the formation of disordered states, only certain individuals are vulnerable to, and therefore experience, these outcomes. Further, females are more likely to be diagnosed with stress-induced psychiatric disorders. Elements within stress neurocircuitry offer insight into differential behavioral outcomes associated with stressful experiences; and the basolateral amygdala (BLA), where pro- and anti-stress signals are integrated, is likely an important mediator in phenotype development. The orexin system, too, while being strongly associated with sleep, motivation, and …
Transgenerational Differences Between Two Culturally Distinct Prairie Vole Populations, Richard Joaquin Ortiz
Transgenerational Differences Between Two Culturally Distinct Prairie Vole Populations, Richard Joaquin Ortiz
Open Access Theses & Dissertations
Culture can be described as a system of environmental beliefs, values, and social practices within one’s environment. This system is passed on from generation to generation and provides a basis for an individual’s behaviors and cognitive perceptions. Cultural neuroscience is an emerging field that intertwines domains of anthropology, psychology, neuroscience, and genetics to help understand the underlying processes, neural mechanisms and genomic factors that vary across cultures. Similar to humans, the socially monogamous prairie vole (Microtus ochrogaster) display populational differences in prosocial behavior and aggression based upon region-specific cultural upbringing and parental lineage. Prairie voles originating from Kansas (KS) display …
Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann
Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann
Open Access Theses & Dissertations
Mood-related disorders, including depression and anxiety, are prevalent among children and adolescents. This poses a public health challenge, given their adverse impact on these young populations. Treatment with the selective serotonin reuptake inhibitor fluoxetine (FLX) is the first line of pharmacological intervention in pediatric patients suffering from affect-related illnesses. Although the use of this antidepressant has been deemed efficacious in the juvenile population, the enduring neurobiological consequences of adolescent FLX exposure are not well understood. For this reason, we explored for persistent molecular adaptations, in the adult hippocampus, as a function of adolescent FLX pretreatment. To do this, we administered …
Axon Initial Segment Morphology Across Typical Cortical Development And In Mouse Models Of Neurodevelopmental Disorders With A High Incidence Of Epilepsy, Rachel Ali Rodriguez
Axon Initial Segment Morphology Across Typical Cortical Development And In Mouse Models Of Neurodevelopmental Disorders With A High Incidence Of Epilepsy, Rachel Ali Rodriguez
UNLV Theses, Dissertations, Professional Papers, and Capstones
Neurodevelopmental disorders (NDDs) are commonly associated with a high incidence of epileptic seizures which result from excessive firing of neurons. The axon initial segment (AIS) is a neuronal compartment essential for the control of activity patterns of neurons. The AIS undergoes important modifications during development, but the molecular mechanisms that affect the development, morphology, and protein composition of the AIS are still not well understood. We examined AIS morphology of medial prefrontal cortex (mPFC) pyramidal neurons in wildtype mice across development and in two mouse models of NDDs. Results indicate restructurings at the AIS during typical development, some of which …
Multiple Approaches To Auditory Rhythm: Development Of Sustained Musical Beat And The Relation To Language, Development Of Rhythmic Categories Via Iterated Production, And A Meta-Analytic Study Of Neural Entrainment To Beat, Karli Marie Nave
UNLV Theses, Dissertations, Professional Papers, and Capstones
Rhythm is ubiquitous to human communication, coordination, and experience of music. In this dissertation, I address three empirical questions through three different methodologies, all of which contribute to the growing body of literature on human auditory rhythm processing. In Chapter 2, I present a registered report detailing the results of independent conceptual replications of Nozaradan, Peretz, Missal, & Mouraux (2011), all using the same vetted protocol. Listeners performed the same tasks as in Nozaradan et al. (2011), with the addition of behavioral measures of perception. In neuroscience, neural correlates to musical beat perception have been identified, yet little to no …
Designs And Outcomes Of Transcranial Magnetic Stimulation (Tms) And Repetitive Transcranial Magnetic Stimulation (Rtms) Circuits, Daniel Senda
UNLV Theses, Dissertations, Professional Papers, and Capstones
This thesis reports the design and outcomes of several circuits intended for transcranial magnetic stimulation (TMS) and repetitive transcranial magnetic stimulation (rTMS) research. In simple terms, TMS circuits are composed of four main blocks: high voltage power source, energy storage bank, control switch, and coil. Each one of these blocks has characteristics that influence how well the circuit will perform for TMS procedures. A successful TMS research circuit must have the ability to emit controlled electromagnetic pulses through a coil connected to it. For the first block, voltages ranging from 50 V to 2 kV were used. In the second …
Probiotic Intervention Improves Recovery Of Hippocampal Memory And Hippocampal Atrophy Following Disruption From High-Fat Diet In Adult Rats, Sanyourah A. El-Hulu
Probiotic Intervention Improves Recovery Of Hippocampal Memory And Hippocampal Atrophy Following Disruption From High-Fat Diet In Adult Rats, Sanyourah A. El-Hulu
Honors Scholars Collaborative Projects
Presently, lifestyle factors such as chronic high-fat diet (HFD) consumption occurs concomitantly with weight gain and obesity (Gil-Cardoso et al., 2017; Stranahan et al., 2008). In turn, obesity has been associated with impairments to mental functioning, specifically to memory. Human epidemiological studies show that HFD intake containing saturated, and omega-6-fatty acids is associated with worse performance on a cognitive task whereas a lower fat diet containing omega-3-fatty acids is associated with a protective effect against cognitive decline (Zhang et al., 2006; Uranga et al., 2010). One explanation for this is the critical role of the gut bacteria in brain health. …
Neural Mechanisms Underlying The Income-Achievement Gap: The Role Of The Ventral Visual Stream, Maya L. Rosen, Lucy A. Lurie, Kelly A. Sambrook, Andrew N. Meltzoff, Katie A. Mclaughlin
Neural Mechanisms Underlying The Income-Achievement Gap: The Role Of The Ventral Visual Stream, Maya L. Rosen, Lucy A. Lurie, Kelly A. Sambrook, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Children from low-socioeconomic status (SES) households on average exhibit lower academic achievement than their higher-SES peers. We investigated a novel hypothesis that differences in early-developing sensory networks—specifically the ventral visual stream (VVS), which is involved in processing visual stimuli—contribute to SES-related disparities in executive functions (EF) and academic outcomes. We used fMRI to investigate SES-related differences in neural function in children (6–8 years, n = 62) during two attentional tasks involving attention to visual information: cued attention and memory-guided attention. Recruitment of VVS during both tasks was associated with EF and academic achievement, and SES-related differences in VVS activation during …
Contributions Of Emotion Regulation And Brain Structure And Function To Adolescent Internalizing Problems And Stress Vulnerability During The Covid-19 Pandemic: A Longitudinal Study, David G. Weissman, Alexandra M. Rodman, Maya L. Rosen, Steven Kasparek, Makeda Mayes, Margaret A. Sheridan, Lilliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Contributions Of Emotion Regulation And Brain Structure And Function To Adolescent Internalizing Problems And Stress Vulnerability During The Covid-19 Pandemic: A Longitudinal Study, David G. Weissman, Alexandra M. Rodman, Maya L. Rosen, Steven Kasparek, Makeda Mayes, Margaret A. Sheridan, Lilliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Background: Adolescence is a period of increased vulnerability for internalizing problems, particularly following stressful life events. We examined how emotion regulation and brain structure and function were associated with internalizing problems during the COVID-19 pandemic and moderated the association between pandemic-related stressors and internalizing problems. Methods: Data are from a longitudinal sample (N = 145, age range, 10–15 years) strategically assessed at 3 crucial time points: before the COVID-19 pandemic, early during the stay-at-home order period, and again 6 months later. We examined associations of amygdala and hippocampal volume and amygdala activation during an emotional processing task before the pandemic, …
Deciphering The Role Of Hsp110 Chaperones In Diseases Of Protein Misfolding, Unekwu M. Yakubu
Deciphering The Role Of Hsp110 Chaperones In Diseases Of Protein Misfolding, Unekwu M. Yakubu
Dissertations & Theses (Open Access)
Molecular chaperones maintain protein homeostasis (proteostasis) by ensuring the proper folding of polypeptides. Loss of proteostasis has been linked to the onset of numerous neurodegenerative disorders including Alzheimer’s, Parkinson’s, and Huntington’s disease. Hsp110 is a member of the Hsp70 class of molecular chaperones and acts as a nucleotide exchange factor (NEF) for Hsp70, the preeminent Hsp70-family protein folding chaperone. Hsp110 promotes rapid cycling of ADP for ATP, allowing Hsp70 to properly fold nascent or unfolded polypeptides in iterative cycles. In addition to its NEF activity, Hsp110 possesses an Hsp70-like substrate binding domain (SBD) whose biological roles are undefined. Previous work …
Impact Of Xenobiotics On Neuronal Outcomes, Gabriela Henriquez
Impact Of Xenobiotics On Neuronal Outcomes, Gabriela Henriquez
Open Access Theses & Dissertations
Neurodegenerative diseases are a common affliction of the Central Nervous System. They are caused by age, genetics, and environmental factors. Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis are well-known among the host of neurodegenerative disorders, with Alzheimer's disease and Parkinson's disease being the leading pathologies across this canvas. It is known that the pathogenesis of neurodegenerative diseases is multifactorial due to the involvement of genetic mutations, radical-induced protein damage, abnormal aggregation of misfolded proteins, and the formation of amyloid deposits. The amyloid proteins in neurodegenerative disease include Tau and Amyloid (Aβ) in Alzheimer's disease and α-Synuclein in …
Mechanisms For Extracellular Matrix-Dependent Blood-Brain Barrier Dysfunction, Brian Adam Hoettels
Mechanisms For Extracellular Matrix-Dependent Blood-Brain Barrier Dysfunction, Brian Adam Hoettels
Boise State University Theses and Dissertations
Dysfunction of the blood vessels that form the blood-brain barrier (BBB) is observed across various neurological disorders, including multiple sclerosis (MS). As barrier loss culminates in neuronal dysfunction and degeneration, a better understanding of the mechanisms underlying BBB dysfunction is needed.
Tight junctions are multiprotein complexes maintained by the endothelial cells lining the inner blood vessel wall to seal the intercellular space, and their disruption impairs BBB function. In my first chapter, I focus on how tight junctions are altered in CNS inflammatory demyelinating diseases (CNS-IDDs) like MS as BBB dysfunction is one of the earliest known stages in …
Gradient Generating Microfluidic Coculture System For Disease Modeling And Neural Development, Phaneendra Chennampally
Gradient Generating Microfluidic Coculture System For Disease Modeling And Neural Development, Phaneendra Chennampally
Electronic Theses and Dissertations
Cellular microenvironment or cell niche plays an important role in developmental biology and disease pathophysiology. Physical or chemical signals in microenvironment drive the cellular activity. These signaling molecules are generated from the surrounding cells/tissues as part of intercellular communication; a fundamental property of a cell. Dynamic profile of these signaling molecules in the microenvironment plays a pivotal role in transfer of molecular information from cell to cell in disease proliferation or fate determination. Recapitulating these signaling cues in an in vitro study is difficult to achieve using standard cell culture techniques. However microfluidic systems are capable of addressing these issues, …
Effect Of Neighborhood Socioeconomic Disadvantage On Brain Functional Connectivity And Structural Properties In Trauma-Exposed Adults, Elisabeth Kathleen Webb
Effect Of Neighborhood Socioeconomic Disadvantage On Brain Functional Connectivity And Structural Properties In Trauma-Exposed Adults, Elisabeth Kathleen Webb
Theses and Dissertations
Though there has been substantial progress towards understanding brain-behavior relationships and characterizing the neurobiology of psychiatric disorders, research has not translated as expected into novel prevention and treatment of mental health conditions. One limitation may be the emphasis on individual-level variables (e.g., income) and omission of relevant area-level factors (e.g., neighborhood socioeconomic disadvantage). Recently, attention has been directed towards identifying the biological mechanisms by which neighborhoods impact mental health. The chronic stress associated with living in a disadvantaged neighborhood promotes a cascade of maladaptive events, which in turn impact brain structure and functioning. The processes affected by chronic neighborhood stressors …
Contrastive Learning For Unsupervised Auditory Texture Models, Christina Trexler
Contrastive Learning For Unsupervised Auditory Texture Models, Christina Trexler
Computer Science and Computer Engineering Undergraduate Honors Theses
Sounds with a high level of stationarity, also known as sound textures, have perceptually relevant features which can be captured by stimulus-computable models. This makes texture-like sounds, such as those made by rain, wind, and fire, an appealing test case for understanding the underlying mechanisms of auditory recognition. Previous auditory texture models typically measured statistics from auditory filter bank representations, and the statistics they used were somewhat ad-hoc, hand-engineered through a process of trial and error. Here, we investigate whether a better auditory texture representation can be obtained via contrastive learning, taking advantage of the stationarity of auditory textures to …