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Pathogenic Microbiology Commons

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Candida albicans

Dissertations and Theses in Biological Sciences

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Farnesol Signaling In Candida Albicans, Melanie L. Langford Apr 2010

Farnesol Signaling In Candida Albicans, Melanie L. Langford

Dissertations and Theses in Biological Sciences

Candida albicans is a polymorphic fungus that causes a range of disease in humans, from mucosal infections to systemic disease. Its ability to cause disease is linked to conversion between yeast and filamentous forms of growth, and the first quorum-sensing molecule discovered in an eukaryote, farnesol, blocks this transition. In C. albicans, farnesol also kills mating-competent opaque cells, inhibits biofilm formation, protects the cells from oxidative stress, and can be a virulence factor or protective agent in disseminated and mucosal mouse models of infection, respectively. While much emphasis has been placed on determining its effect on C. albicans morphology, the ...