Pathogenic Microbiology Commons^™

Genetic Diversity, Population Structure, And Evolution Of Virulence In Toxoplasma Gondii, Elliot Keats Cullen Shwab

Doctoral Dissertations

Toxoplasma gondii is among the most widespread eukaryotic pathogens known. It chronically infects approximately one third of the world’s human population and has been isolated from an extremely diverse array of globally distributed mammals and birds. Understanding the structure of the worldwide T. gondii population enhances our understanding of the factors that have shaped that structure and led to the proliferation of one of the most evolutionarily successful pathogens on Earth. Herein we collate genotypic data from global isolates, demonstrating that T. gondii possesses a unique population structure in which only a small number of genotypes dominate throughout the northern …