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Pathogenic Microbiology Commons

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Full-Text Articles in Pathogenic Microbiology

Design And Testing Of Novel Anthrax Vaccines Utilizing A Tobacco Mosaic Virus Expression System, Ryan C. Mccomb Dec 2015

Design And Testing Of Novel Anthrax Vaccines Utilizing A Tobacco Mosaic Virus Expression System, Ryan C. Mccomb

KGI Theses and Dissertations

Anthrax is a potentially fatal disease caused by the bacteria Bacillus anthracis. Infection and disease occur after spores gain entry into the body, germinate into vegetative bacteria, and produce toxin. Bacillus anthracis spores have been engineered as bioweapons and have been used repeatedly in warfare and terrorism to inflict casualties in military and civilian populations. Currently, only one vaccine has been approved for prevention of anthrax in the United States. This vaccine is an undefined product that is difficult to produce, requires a long vaccination schedule, and is reactogenic. Efforts to make an improved anthrax vaccine are being pursued. With ...


Prevalence Of A Chytrid Pathogen (Batrachochytrium Dendrobatidis) In Eastern Hellbender Salamanders In New York And Pennsylvania, Linxuan Wu Aug 2015

Prevalence Of A Chytrid Pathogen (Batrachochytrium Dendrobatidis) In Eastern Hellbender Salamanders In New York And Pennsylvania, Linxuan Wu

Biology Theses

Amphibian populations are currently declining globally. There are many possible causes for these declines, among which an emerging infectious disease, chytridiomycosis, has been implicated. Chytridiomycosis in the U.S.A. is mainly caused by the Batrachochytrium dendrobatidis. In this study, I used qPCR assays to detect the existence of this pathogen in the Eastern Hellbender (Cryptobranchus alleganiensis alleganiensis) populations in the Allegheny and Susquehanna River drainages of New York and Pennsylvania. Chytrid is most often tested by using skin swabs, but in this study, tail clips, dorsal skin, blood and eggs were tested as well. Batrachochytrium dendrobatidis was detected in ...


Strain Typing Mycobacterium Marinum From Outbreaks At Zebrafish Research Facilities, Brooke M. Clemons Jan 2015

Strain Typing Mycobacterium Marinum From Outbreaks At Zebrafish Research Facilities, Brooke M. Clemons

Honors Theses

Zebrafish (Danio rerio) are used as model organisms for biological research due to their rapid and transparent development and high fecundity amongst other reasons. Research has expanded beyond embryonic studies, with adult fish used for longer-term studies such as human disease and senescence. Zebrafish are often housed at high density in large colonies. As with any similar husbandry situation, diseases can occur, with impacts that range from morbidity to premature mortality costing researchers time and money. Understanding the impact of underlying diseases in zebrafish is crucial, particularly for long-term studies where chronic infections may confound results. One such disease problem ...