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Multilayered Regulation Of The Type I Toxin Zoro In Ehec, Jia Wen
Multilayered Regulation Of The Type I Toxin Zoro In Ehec, Jia Wen
Doctoral Dissertations
A bacterial type I toxin-antitoxin system contains two genes: one encodes a small toxic protein and the second, a small regulatory RNA (sRNA) that inhibits toxin production. To date, very few type I loci have been described thoroughly in regards to the regulation of toxin and the function of the toxin at endogenous levels. In this study, I demonstrated that the zor-orz locus of Escherichia coli O157:H7 is composed of two highly homologous type I toxin-antitoxin systems: zorO-orzO and zorP-orzP. The zor genes encode the toxins and the orz genes encode the antitoxin sRNAs. Overexpression of zorO is toxic …