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Full-Text Articles in Pathogenic Microbiology
Trypanosoma Brucei Mitochondrial Dna Polib Cell Cycle Localization And Effect On Polic When Polib Is Depleted, Sylvia L. Rivera
Trypanosoma Brucei Mitochondrial Dna Polib Cell Cycle Localization And Effect On Polic When Polib Is Depleted, Sylvia L. Rivera
Masters Theses
Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT), also known as African sleeping sickness. T. brucei is unique in several ways that distinguish this organism from other eukaryotes. One of the unique features of T. brucei is the organism’s mitochondrial DNA, which is organized in a complex structure called kinetoplast DNA (kDNA). Since kDNA is unique to the kinetoplastids, kDNA may serve as a good drug target against T. brucei. Previews studies have shown that kDNA has 4 different family A mitochondrial DNA polymerases. Three of these mitochondrial DNA polymerases (POLIB, POLIC, and POLID) are essential …