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Full-Text Articles in Cell Biology
Actinomycin D And Telmisartan Combination Therapy Targets Lung Cancer Stem Cells, Ryan Green
Actinomycin D And Telmisartan Combination Therapy Targets Lung Cancer Stem Cells, Ryan Green
USF Tampa Graduate Theses and Dissertations
The failure of lung cancer treatments has been attributed partly to the development of drug resistance, however the underlying cellular and molecular mechanisms are poorly understood. It has been suggested that a very small group of specific cells within the heterogeneous tumors, cancer initiating stem cells (CSC), develop resistance to treatment, survive and later initiate the growth of new tumors. Due to their pivotal role in maintenance and relapse of tumors following the acquisition of drug resistance, we reasoned that novel drugs targeting cancer cells and CSC might provide the most effective treatments, if not a cure. To this end, …
The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay
The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay
Theses and Dissertations in Biomedical Sciences
The targeting of proven anticancer drugs specifically to cancer cells would provide a unique opportunity to restrict neoplasms without damaging the cancer patient. The present research utilizes the phenomenon of illicit transport, i.e. the coupling of normally impermeant metabolites to permeant metabolites, in targeting the drug melphalan to mouse Ehrlich ascites tumor cells. The dipeptide beta-alanyl-melphalan was synthesized and tested in vitro for toxicity towards mouse Ehrlich ascites tumor cells, mouse liver cells, and mouse 3T3 embryonic cells. The parent compound, melphalan, was used as a control treatment. In addition, both melphalan and beta-alanyl-melphalan were utilized in in vivo chemotherapeutic …