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Dietary Exposure To 2,2´,4,4´-Tetrabromodiphenyl Ether (Pbde-47) Alters Thyroid Status And Thyroid Hormone–Regulated Gene Transcription In The Pituitary And Brain, Sean C. Lema, Jon T. Dickey, Irvin R. Schultz, Penny Swanson
Dietary Exposure To 2,2´,4,4´-Tetrabromodiphenyl Ether (Pbde-47) Alters Thyroid Status And Thyroid Hormone–Regulated Gene Transcription In The Pituitary And Brain, Sean C. Lema, Jon T. Dickey, Irvin R. Schultz, Penny Swanson
Biological Sciences
No abstract provided.
Molecular Cloning And Sequence Analysis Of Multiple Cdna Variants For Thyroid-Stimulating Hormone Β Subunit (Tshβ) In The Fathead Minnow (Pimephales Promelas), Sean C. Lema, Jon T. Dickey, Penny Swanson
Molecular Cloning And Sequence Analysis Of Multiple Cdna Variants For Thyroid-Stimulating Hormone Β Subunit (Tshβ) In The Fathead Minnow (Pimephales Promelas), Sean C. Lema, Jon T. Dickey, Penny Swanson
Biological Sciences
We cloned and sequenced full-length cDNAs encoding the β subunit of thyroid-stimulating hormone (TSHβ) from the pituitary of fathead minnow (Piephales promelas)using 5'-and 3'-rapid amplification of cDNA ends (RACE). Three cDNA variants for TSHβ with lengths of 1184-, 1093-, and 818-bp were identified. The cDNA variant of 1184-bp included 453-bp of open-reading frame and 610-bp of 3' UTR followed by a poly(A)site. This cDNA encodes 150 amino acids including a 19 residue signal peptide and a mature TSHβ protein of 131 residues with sequence identities of 97–53% to other fishes and 42–39% to mammals. The 1093-bp cDNA variant …