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Full-Text Articles in Bioinformatics

Bottlenecks In The Open-Access System: Voices From Around The Globe, Shaily Menon Dec 2013

Bottlenecks In The Open-Access System: Voices From Around The Globe, Shaily Menon

Shaily Menon

A level playing field is key for global participation in science and scholarship, particularly with regard to how scientific publications are financed and subsequently accessed. However, there are potential pitfalls of the so-called “Gold” open-access (OA) route, in which author-paid publication charges cover the costs of production and publication. Gold OA plans in which author charges are required may not solve the access problem, but rather may shift the access barrier from reader to writer. Under such plans, everyone may be free to read papers, but it may still be prohibitively expensive to publish them. In a scholarly community that …


Bioinformatics Analyses Of Chromium Tolerant Genes In Cyanobacteria And Identification Of Their Operon In Synechococcus Sp. Iu 625, Lee Lee, Richard Garrett, Anna Slusarczyk, Jose Perez, Tin-Chun Chu Jul 2013

Bioinformatics Analyses Of Chromium Tolerant Genes In Cyanobacteria And Identification Of Their Operon In Synechococcus Sp. Iu 625, Lee Lee, Richard Garrett, Anna Slusarczyk, Jose Perez, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Inhibition Of Herpes Simplex Virus Type 1 With The Modified Green Tea Polyphenol Pamitoyl-Epigallocatechin Gallate., Aline De Oliveira, Sandra Adams, Lee Lee, Sean Murray, Stephen Hsu, Jeffrey Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu Oct 2012

Inhibition Of Herpes Simplex Virus Type 1 With The Modified Green Tea Polyphenol Pamitoyl-Epigallocatechin Gallate., Aline De Oliveira, Sandra Adams, Lee Lee, Sean Murray, Stephen Hsu, Jeffrey Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Epigallocatechin-3-Gallate Modulates Oxidative Stress In Exocrine Glands Of A Primary Sjogren’S Syndrome Mouse Model Prior To Disease Onset, Seiji Ohno, Hongfang Yu, Douglas Dickinson, Tin-Chun Chu, Kalu Ogbureke, Scott Derossi, Tetsuya Yamamoto, Stephen Hsu Oct 2012

Epigallocatechin-3-Gallate Modulates Oxidative Stress In Exocrine Glands Of A Primary Sjogren’S Syndrome Mouse Model Prior To Disease Onset, Seiji Ohno, Hongfang Yu, Douglas Dickinson, Tin-Chun Chu, Kalu Ogbureke, Scott Derossi, Tetsuya Yamamoto, Stephen Hsu

Tin-Chun Chu, Ph.D.

No abstract provided.


Protamine-Like Proteins In 12 Sequenced Species Of Drosophila, Zain Alvi, Tin-Chun Chu, Valerie Schawaroch, Angela Klaus Jul 2012

Protamine-Like Proteins In 12 Sequenced Species Of Drosophila, Zain Alvi, Tin-Chun Chu, Valerie Schawaroch, Angela Klaus

Tin-Chun Chu, Ph.D.

No abstract provided.


Identification And Bioinformatic Analyses Of Vanillate Operon In Cyanobacterium Synechococcus Sp. Iu 625, Robert Newby, Tin-Chun Chu Jun 2012

Identification And Bioinformatic Analyses Of Vanillate Operon In Cyanobacterium Synechococcus Sp. Iu 625, Robert Newby, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Bioinformatic Analysis Of Cyanobacterial Mercuric Resistance Genes And Identification Of Synechococcus Sp. Iu 625 Putative Mercuric Resistance Genes, Lee Lee, Chiedozie Okafor, Matthew Rienzo, Tin-Chun Chu Jun 2012

Bioinformatic Analysis Of Cyanobacterial Mercuric Resistance Genes And Identification Of Synechococcus Sp. Iu 625 Putative Mercuric Resistance Genes, Lee Lee, Chiedozie Okafor, Matthew Rienzo, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.


Effects Of Single-Nucleotide Polymorphisms In The Human Holocarboxylase Synthetase Gene On Enzyme Catalysis, Sridhar Malkaram, Shingo Esaki, Janos Zempleni Dec 2011

Effects Of Single-Nucleotide Polymorphisms In The Human Holocarboxylase Synthetase Gene On Enzyme Catalysis, Sridhar Malkaram, Shingo Esaki, Janos Zempleni

Sridhar A Malkaram

No abstract provided.


Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen Jul 2010

Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen

Jorge L. Yarzebski

As part of a community-based study of patients hospitalized with acute myocardial infarction (AMI) in the Worcester, Massachusetts, metropolitan area, changes over time in the incidence rates of complete heart block (CHB) complicating AMI, and the prognostic impact of CHB on the in-hospital and long-term survival of these patients were examined. In all, 4,762 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988 constituted the study sample. The incidence rates of CHB complicating AMI remained relatively stable at 5.8% over the 13-year (1975 to 1988) period studied. The …


Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore Jul 2010

Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore

Jorge L. Yarzebski

BACKGROUND: The objectives of our study were to examine long-term (1986-2003) trends in the use of percutaneous coronary interventions (PCI) and thrombolytic therapy in the management of patients hospitalized at all Central Massachusetts medical centers with acute myocardial infarction (AMI). Our secondary study goal was to examine factors associated with use of these coronary reperfusion strategies. Limited contemporary data are available about changing trends in the use of coronary reperfusion strategies, particularly from a population-based perspective. METHODS: The sample consisted of 9422 greater Worcester (MA) residents hospitalized with AMI at all metropolitan Worcester medical centers in 10 annual periods between …


A Community-Wide Perspective Of Gender Differences And Temporal Trends In The Use Of Diagnostic And Revascularization Procedures For Acute Myocardial Infarction, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Z. Chen, Jerry Gurwitz, Joel Gore, Joseph Alpert, James Dalen Jul 2010

A Community-Wide Perspective Of Gender Differences And Temporal Trends In The Use Of Diagnostic And Revascularization Procedures For Acute Myocardial Infarction, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Z. Chen, Jerry Gurwitz, Joel Gore, Joseph Alpert, James Dalen

Jorge L. Yarzebski

This study compares the overall use, as well as temporal trends, of various diagnostic and revascularization procedures for acute myocardial infarction (AMI) in men and women. The study sample comprised a total of 2,924 men and 1,838 women with validated AMI admitted to any of the 16 teaching and community hospitals in the Worcester, Massachusetts, metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988. During the period under study there was a significant increase in use of each of the examined procedures during hospitalization for AMI in both men and women. Increasing use of multiple procedures was also seen …


Temporal Trends And Factors Associated With Extent Of Delay To Hospital Arrival In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert Jul 2010

Temporal Trends And Factors Associated With Extent Of Delay To Hospital Arrival In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert

Jorge L. Yarzebski

Factors associated with delay to hospital arrival after the onset of symptoms suggestive of acute myocardial infarction (AMI) were examined in the late 1960s and 1970s, but recent data concerning these characteristics are limited. The purpose of the present study was to examine overall and temporal distributions of the extent of patients' delay from the time of onset of AMI symptoms to hospital arrival and factors associated with delay in seeking medical care from a multihospital, population-based perspective. Review of medical records was undertaken of patients hospitalized with a discharge diagnosis of AMI in 16 teaching and community hospitals in …


Patient Delay And Receipt Of Thrombolytic Therapy Among Patients With Acute Myocardial Infarction From A Community-Wide Perspective, Robert Goldberg, Jerry Gurwitz, Jorge Yarzebski, J. Landon, Joel Gore, Joseph Alpert, P. Dalen, James Dalen Jul 2010

Patient Delay And Receipt Of Thrombolytic Therapy Among Patients With Acute Myocardial Infarction From A Community-Wide Perspective, Robert Goldberg, Jerry Gurwitz, Jorge Yarzebski, J. Landon, Joel Gore, Joseph Alpert, P. Dalen, James Dalen

Jorge L. Yarzebski

The duration of patient delay from the time of onset of symptoms of acute myocardial infarction (AMI) to hospital presentation, and the relation of delay time and various patient characteristics to receipt of thrombolytic therapy were examined as part of a community-based study of patients hospitalized with AMI in the Worcester, Massachusetts, metropolitan area. In all, 800 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area in 1986 and 1988 constituted the study sample. Patients delayed on average 4 hours between noting symptoms suggestive of AMI and presenting to area-wide emergency departments with no significant change …


Identification Of Cancer-Associated Gene Pathways From Analysis Of Expression Data, Shuangge Ma Aug 2009

Identification Of Cancer-Associated Gene Pathways From Analysis Of Expression Data, Shuangge Ma

Shuangge Ma

No abstract provided.


Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee Jun 2009

Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Lecture 5, Shuangge Ma Jun 2009

Lecture 5, Shuangge Ma

Shuangge Ma

No abstract provided.


Final Project, Shuangge Ma Jun 2009

Final Project, Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 4, Shuangge Ma Jun 2009

Lecture 4, Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 4, Shuangge Ma Jun 2009

Lecture 4, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 13, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 13, Shuangge Ma

Shuangge Ma

No abstract provided.


Final Project (Description), Shuangge Ma Jun 2009

Final Project (Description), Shuangge Ma

Shuangge Ma

No abstract provided.


Final Project (Data), Shuangge Ma Jun 2009

Final Project (Data), Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 3, Shuangge Ma Jun 2009

Lecture 3, Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 2, Shuangge Ma Jun 2009

Lecture 2, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Multiple Imputation, Shuangge Ma Jun 2009

Reference: Multiple Imputation, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Weighted Bootstrap, Shuangge Ma Jun 2009

Reference: Weighted Bootstrap, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 9, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 9, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 8, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 8, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Counter Examples [Bootstrap], Shuangge Ma Jun 2009

Reference: Counter Examples [Bootstrap], Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 7 (Lab 2), Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 7 (Lab 2), Shuangge Ma

Shuangge Ma

No abstract provided.