Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Zoology and genetics

Zoology

2003

Articles 1 - 1 of 1

Full-Text Articles in Molecular Biology

Posttranslational Processing And Functional Analysis Of Tractin, An L1 Family Member In Leech , Yingzhi Xu Jan 2003

Posttranslational Processing And Functional Analysis Of Tractin, An L1 Family Member In Leech , Yingzhi Xu

Retrospective Theses and Dissertations

During neurogenesis, glycosylated cell adhesion molecules (CAMs) mediate the growth cone navigation and synapse formation. The structure of neuronal CAMs of Ig superfamily is characterized by the variability and complexity of their extracellular region which contain multiple tandemly arranged domains. The diversity in the structure of the neuronal CAMs is generated by alternative splicing and posttranslational modification, such as differential glycosylation and proteolytic processing.;Tractin is a member of the L1-family of neuronal CAMs in leech. It contains six Ig domains, 4 FNIII-like domains, an acidic domain, 12 repeats of a novel proline- and glycine-rich motif (PG/YG) with sequence ...