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Zoology and genetics

Zoology

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Full-Text Articles in Molecular Biology

Posttranslational Processing And Functional Analysis Of Tractin, An L1 Family Member In Leech , Yingzhi Xu Jan 2003

Posttranslational Processing And Functional Analysis Of Tractin, An L1 Family Member In Leech , Yingzhi Xu

Retrospective Theses and Dissertations

During neurogenesis, glycosylated cell adhesion molecules (CAMs) mediate the growth cone navigation and synapse formation. The structure of neuronal CAMs of Ig superfamily is characterized by the variability and complexity of their extracellular region which contain multiple tandemly arranged domains. The diversity in the structure of the neuronal CAMs is generated by alternative splicing and posttranslational modification, such as differential glycosylation and proteolytic processing.;Tractin is a member of the L1-family of neuronal CAMs in leech. It contains six Ig domains, 4 FNIII-like domains, an acidic domain, 12 repeats of a novel proline- and glycine-rich motif (PG/YG) with sequence ...


Molecular Analysis Of Protein Kinase C In The Sea Urchin Lytechinus Pictus , Terese Louise Rakow Jan 1993

Molecular Analysis Of Protein Kinase C In The Sea Urchin Lytechinus Pictus , Terese Louise Rakow

Retrospective Theses and Dissertations

Protein kinase C (PKC) was originally described as a serine threonine kinase in brain tissue. This activity was found to be dependent upon Ca[superscript]2+ and phosphatidyl serine. Today protein kinase C consists of a family of kinases with nine known members. Some members are Ca[superscript]2+-independent isozymes, and all of them have subtle activation differences. The multiple isozymes with varying activities in addition to different tissue distributions lead to the idea that members of the family have different functions. PKC has been well studied in mammalian systems and it is concluded that PKC is activated in ...


Characterization Of Cis-Acting Replication Control Elements In Ribosomal Rna Genes Of Tetrahymena Thermophila , Wen-Ling Shaiu Jan 1993

Characterization Of Cis-Acting Replication Control Elements In Ribosomal Rna Genes Of Tetrahymena Thermophila , Wen-Ling Shaiu

Retrospective Theses and Dissertations

This dissertation describes the identification and characterization of specific cis-acting replication control elements in the replication origin of Tetrahymena rDNA. Earlier studies of a mutant rDNA allele, C3-rmm1, identified a cis-acting sequence (the Type I repeat) within the 5[superscript]' non-transcribed spacer of rDNA that affects rDNA replication (Larson et al. 1986). Characterization of two additional, independently-isolated mutants (C3-rmm3 and C3-rmm4) and a revertant of C3-rmm4 strongly argue that the Type I repeat is indeed a cis-acting replication control element. Mutations causing rDNA replication defects were identified in copies of the Type I repeat that are separated by >600 bp ...


Identification Of The Immediate-Early Products Of Bovine Herpesvirus-1 , David A. Hulce Jan 1990

Identification Of The Immediate-Early Products Of Bovine Herpesvirus-1 , David A. Hulce

Retrospective Theses and Dissertations

Bovine herpesvirus-1 (BHV-1) is a member of the alphaherpesvirinae. Productive infections of the alphaherpesvirinae progress through three stages of viral transcription and translation. The first stage, immediate-early (IE), does not require prior viral gene expression and is required for the second, delayed-early (DE), and third, late (L), stages of the infectious cycle. Like other herpesviruses, BHV-1 frequently establishes latent infections. This study was undertaken to characterize the IE stage of the productive BHV-1 infection. The number and location of IE genes and the size of IE polypeptides and IE mRNAs were investigated;Probing genomic Southern blots of BHV-1 cloned in ...