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Full-Text Articles in Molecular Biology
Gene Mapping Of Monogenic Disorders And Complex Diseases Via Genome Wide Association Studies, Xia Zhao
Graduate Theses and Dissertations
Inherited rickets, lower motor neuron disease and chondrodysplasia were recently reported genetic disorders that had been identified on sheep farms in New Zealand. Animals with rickets showed softening and weakening bone, and were characterized by decreased growth rate, thoracic lordosis and angular limb deformities. Sheep diagnosed with lower motor neuron disease were characterized by poor muscle tone and progressive weakness from about one week of age, leading to severe tetraparesis, recumbency and muscle atrophy. Chondrodysplasia in Texel sheep was characterized by dwarfism and angular deformities of the forelimbs. These three disorders were determined likely simple autosomal recessive by backcross breeding ...