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Adipogenic commitment

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Amplification Of Adipogenic Commitment By Vstm2a, Blandine Secco, Peter L. Lee, David A. Guertin, Mathieu Laplante Jan 2017

Amplification Of Adipogenic Commitment By Vstm2a, Blandine Secco, Peter L. Lee, David A. Guertin, Mathieu Laplante

UMass Metabolic Network Publications

Despite progress in our comprehension of the mechanisms regulating adipose tissue development, the nature of the factors that functionally characterize adipose precursors is still elusive. Defining the early steps regulating adipocyte development is needed for the generation of tools to control adipose tissue size and function. Here, we report the discovery of V-set and transmembrane domain containing 2A (VSTM2A) as a protein expressed and secreted by committed preadipocytes. VSTM2A expression is elevated in the early phases of adipogenesis in vitro and adipose tissue development in vivo. We show that VSTM2A-producing cells associate with the vasculature and express the common surface ...