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Articles 1 - 7 of 7
Full-Text Articles in Molecular Biology
P-20 Characterization Of Cgx Tautomerase And Mutants With Acetylenecarboxylic Acid, Daniel Chi, Karen Draths, Amaya Sirinimal
P-20 Characterization Of Cgx Tautomerase And Mutants With Acetylenecarboxylic Acid, Daniel Chi, Karen Draths, Amaya Sirinimal
Celebration of Research and Creative Scholarship
In the production of commodity chemicals through microbial synthesis, the use of renewable sugars as a raw material is increasingly common. However, this generates competition between its use in the chemical industry and the food industry. Therefore, developing alternative biosynthetic pathways involving other renewable feedstocks to replace starch-derived feedstocks is crucial. CgX, a tautomerase native to Corynebacterium glutamicum, catalyzes the hydration and subsequent decarboxylation of acetylenecarboxylic acid (ACA), a compound that can be produced from methane gas and carbon dioxide, both abundant greenhouse gases. The products formed from the CgX (wild-type)-catalyzed reaction of ACA results in a mixture of …
Knocking Out A Negative Regulator Of Hedgehog Signaling Blocks Differentiation Of Cells Into Neurons, Danielle Margaret Spice, Gregory M. Kelly Ph.D.
Knocking Out A Negative Regulator Of Hedgehog Signaling Blocks Differentiation Of Cells Into Neurons, Danielle Margaret Spice, Gregory M. Kelly Ph.D.
Western Research Forum
Hedgehog (Hh) signaling, one of many different protein signaling pathways found in mammals, is vital in many stage of neural development. A major negative regulator of Hh signaling is a protein known as Suppressor of Fused (SUFU), which acts to sequester the full length Gli transcription factors, proteins that can turn genes on and off, in the cytoplasm or facilitates its conversion to a repressive form. The P19 embryonal carcinoma cell line is a model of hind-brain neuronal differentiation and the involvement of Hh signaling, in particular the role of SUFU in this process has yet to be explored. We …
Stochastic Modeling Of Neuronal Transport In Various Cellular Geometries, Abhishek Choudhary Mr., Peter Kramer
Stochastic Modeling Of Neuronal Transport In Various Cellular Geometries, Abhishek Choudhary Mr., Peter Kramer
Biology and Medicine Through Mathematics Conference
No abstract provided.
Cell Separation Delay And Membrane Trafficking Defects In Cdc42 Gap Mutants, Haylee Grace Young
Cell Separation Delay And Membrane Trafficking Defects In Cdc42 Gap Mutants, Haylee Grace Young
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Cytokinesis is the final step in cell division, where a cell separates into two daughter cells. Cytokinesis involves many steps that must be organized in a spatiotemporal manner. In many eukaryotes, it involves the assembly and constriction of an actomyosin ring. The fission yeast Schizosaccharomyces pombe serves as a good model system to study cytokinesis because they divide via actomyosin-dependent-cytokinesis.
The Rho-family of small GTPases are molecules involved in the regulation of cell growth and division. The GTPase Cdc42 helps promote timely onset of ring constriction and septum formation in fission yeast. Studies with many other organisms show that Cdc42 …
Pilot Studies Of Two Possible Iron Uptake Mechanisms In Insect Cells, Michelle Coca
Pilot Studies Of Two Possible Iron Uptake Mechanisms In Insect Cells, Michelle Coca
Kansas State University Undergraduate Research Conference
Pilot Studies of Two Possible Iron Uptake Mechanisms in Insect Cells
Michelle E. Coca, Diana G. Najera, and Dr. Maureen J. Gorman
Department of Biochemistry and Molecular Biophysics
College of Arts and Sciences
Iron plays an important role in energy metabolism and other essential physiological processes; however, because iron can also be toxic, its uptake by cells must be strictly regulated. In humans, there is a well-understood pathway of iron uptake and multiple poorly understood pathways. How iron is transported into insect cells is unknown. The goal of this study was to test two models of iron uptake by cultured …
Ultrafine Carbon Nanoparticles Activate Inflammasome Signaling And Cell Death In Murine Macrophages, Alexander Soloniuk, Hadley Lamascus, Jay Brewster, John Mann
Ultrafine Carbon Nanoparticles Activate Inflammasome Signaling And Cell Death In Murine Macrophages, Alexander Soloniuk, Hadley Lamascus, Jay Brewster, John Mann
Seaver College Research And Scholarly Achievement Symposium
Carbon black (CB) is the primary nanoparticulate component of air pollution from fossil fuel combustion. This work examines the cellular impact of ultrafine carbon (carbon black, CB) nanoparticles, that range in size down to 30 nm, upon murine macrophages. The size analysis of the carbon black nanoparticles was performed using atomic force microscopy (AFM) and transmission electron microscopy (TEM) techniques. RAW246.7 macrophage cells were exposed to CB doses ranging from 50 – 200 ug/ml in complete media. Analysis of cell survival over time revealed elevated rates of significant nuclear degradation and cell lifting after 48 hours of exposure, and in …
Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Matthew M. Froid
Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Matthew M. Froid
UNO Student Research and Creative Activity Fair
Properties emerge from the dynamics of large-scale molecular networks that are not discernible at the individual gene or protein level. Mathematical models - such as probabilistic Boolean networks - of molecular systems offer a deeper insight into how these emergent properties arise. Here, we introduce a non-linear, deterministic Boolean model of protein, gene, and chemical interactions in human macrophage cells during HIV infection. Our model is composed of 713 nodes with 1583 interactions between nodes and is responsive to 38 different inputs including signaling molecules, bacteria, viruses, and HIV viral particles. Additionally, the model accurately simulates the dynamics of over …