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Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2017

Cancer Biology

PhD theses

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Full-Text Articles in Molecular Biology

Mirna-124-3p Reduces Cell Viability In Cisplatin Resistant Neuroblastoma Cell Models., John Christopher Nolan Jul 2017

Mirna-124-3p Reduces Cell Viability In Cisplatin Resistant Neuroblastoma Cell Models., John Christopher Nolan

PhD theses

Neuroblastoma is a highly heterogeneous disease, responsible for 15 % of paediatric cancer deaths. Acquired drug resistance is a major obstacle in high risk neuroblastoma, making the elucidation of mechanisms in development and modulation of drug resistance essential.

Three drug-resistant models, KellyCis83, CHP212Cis100 and SK-N-ASCis24 were developed previously to elucidate mechanisms involved in cisplatin resistance development.

Cisplatin resistance induces phenotypic changes in neuroblastoma. The aim of this work was to characterise phenotypic and proteomic changes and validate a miRNA capable of regulating the expression of up-regulated genes from proteomic analysis of cisplatin resistant sub-lines.

Proteomic profiling was carried out on the ...