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Full-Text Articles in Molecular Biology
Polymerase Alpha Components Associate With Telomeres To Mediate Overhang Processing, Raffaella Diotti
Polymerase Alpha Components Associate With Telomeres To Mediate Overhang Processing, Raffaella Diotti
Dissertations, Theses, and Capstone Projects
Telomeres consist of TTAGGG repeats, which end with a 3' G-overhang and are bound by a six-protein complex, known as Shelterin. In humans, telomeres shorten at each cell division, unless telomerase is expressed and able to add telomeric repeats to the 3' G-overhang. However, for effective telomere maintenance, the DNA strand complementary to that made by telomerase must be synthesized. In this study, I focused on the Polα/primase complex, in particular the subunits p68 (POLA2, the regulatory subunit) and p180 (Polα, the catalytic subunit), and their potential roles at telomeres. I was able to detect p180, p68 and OBFC1, a …
The Sex Of The Cell Dictates Its Response, Carlos Ganesh Penaloza
The Sex Of The Cell Dictates Its Response, Carlos Ganesh Penaloza
Dissertations, Theses, and Capstone Projects
Male and female differences in frequency of occurrence in disease have perplexed scientists for some time. This in part derives from limitations in the systems in which one can evaluate sex differences. At the organismal level, differences can be hidden by a myriad of extensive and complex factors. Additional limitations exist since most biomedical studies are performed almost exclusively on male subjects, as the female hormonal milieu is intrinsically more variable and too troublesome for routine inclusion in research protocols. Research documenting sex differences continues to grow, and while most researchers suggests that sex hormones are at the core of …