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Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

1990

Iowa State University

Biochemistry and biophysics

Biochemistry

Articles 1 - 2 of 2

Full-Text Articles in Molecular Biology

Regulation Of Protein Expression By Transforming Growth Factor Beta And Other Growth Modulators , Frederic William Thalacker Jan 1990

Regulation Of Protein Expression By Transforming Growth Factor Beta And Other Growth Modulators , Frederic William Thalacker

Retrospective Theses and Dissertations

The main goal of this project was to understand the signal transduction pathways through which growth modulators such as TGF-[beta], PMA and retinoic acid mediate protein expression and DNA synthesis. Transforming growth factor [beta] (TGF-[beta]) induces synthesis and secretion of a 48,000 M r protein that we have found to be type I plasminogen activator inhibitor (PAI-1). TGF-[beta] induces PAI-1 in every cell line that we have studied including near term mink lung epithelial CCL64 cells, mouse embryo fibroblast AKR-2B 84A cells, African green monkey kidney epithelial BSC-1 cells, and normal rat kidney fibroblast NRK 49F ...


Analysis And Characterization Of The Major Histocompatibility Complex Of Domestic Animals , Yuanxin Xu Jan 1990

Analysis And Characterization Of The Major Histocompatibility Complex Of Domestic Animals , Yuanxin Xu

Retrospective Theses and Dissertations

The major histocompatibility complex (MHC) is a family of genes coding for molecules which play important roles in the immune response as well as many other cellular processes of a vertebrate organism. The understanding of the immune system of some of the domestic animals will have both practical value and theoretical significance. The purpose of this work was to study the MHC of the chicken (B) and the swine (SLA). First, in order to study the MHC class II gene structure of the chicken, a genomic library was constructed from an inbred chicken line G-B2 (MHC haplotype B[superscript]6 ...