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Molecular Biology Commons

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Theses/Dissertations

And developmental biology

2003

Veterinary Medicine

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Full-Text Articles in Molecular Biology

Genetic And Phenotypic Variation Of The Equine Infectious Anemia Virus Surface Unit Envelope Glycoprotein During Disease Progression , Brett Alan Sponseller Jan 2003

Genetic And Phenotypic Variation Of The Equine Infectious Anemia Virus Surface Unit Envelope Glycoprotein During Disease Progression , Brett Alan Sponseller

Retrospective Theses and Dissertations

Lentiviruses are single-stranded RNA viruses generally associated with chronic diseases of the immune and central nervous systems. In contrast to the insidious, progressive nature of most lentiviral diseases, equine infectious anemia virus (EIAV) infection results in rapid onset of a variable disease course in equids. Acute disease is accompanied with high-titered viremia, thrombocytopenia, fever, depression, and inappetance. The chronic stage is usually characterized by recurrent episodes of disease. Equids that survive recurrent disease episodes progress to the inapparent stage of disease where no clinical signs are evident; however, there is persistent, ongoing virus replication. Lentiviruses exist within the host as ...