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Molecular Biology Commons

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Theses/Dissertations

And developmental biology

1998

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Full-Text Articles in Molecular Biology

Investigating The Mechanism Of Mrp/Plf Gene Expression By Bfgf , Alesia Marie Hruska-Hageman Jan 1998

Investigating The Mechanism Of Mrp/Plf Gene Expression By Bfgf , Alesia Marie Hruska-Hageman

Retrospective Theses and Dissertations

The mitogen-regulated protein/proliferin (mrp/ plf) genes belong to the prolactin/growth hormone gene superfamily and encode at least four closely related proteins. Identified functions of these proteins include stimulation of uterine proliferation and endothelial angiogenesis. In 3T3 cells, basic fibroblast growth factor (bFGF) stimulates the production of mrp/plf mRNAs with a resulting increase in the protein products. Although the three cloned mrp/ plf gene promoters (mrp3, plf42, and plf149 ) are over 97% identical in sequence, only mrp3 is transcriptionally activated by bFGF. We have identified a sequence in the mrp3 promoter, which we have named the "bFGF-responsive element ...