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Molecular Biology Commons

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Theses/Dissertations

And developmental biology

1987

Articles 1 - 2 of 2

Full-Text Articles in Molecular Biology

The Metabolism And Localization Of Two Proteins During Heat Shock Of Tetrahymena Thermophila , Thomas William Mcmullin Jan 1987

The Metabolism And Localization Of Two Proteins During Heat Shock Of Tetrahymena Thermophila , Thomas William Mcmullin

Retrospective Theses and Dissertations

When T. thermophila is subjected to hyperthermal stress, it immediately but transiently represses the synthesis of the normal array of proteins (non-hsps) and induces the synthesis of the heat shock protein (hsps). These changes in protein synthetic patterns are controlled at both the transcriptional and translational levels;To determine whether the translational regulatory events could be correlated with changes in the protein synthetic machinery, heat shock induced modifications of the ribosomal proteins were investigated. Of particular interest was the heat shock induced association of a 22 kDa protein, p22, with the small subunit of the ribosome. The synthesis of p22 ...


The Mouse Major Histocompatibility Complex And Age-Related Changes In The Murine Immune System , Terry Euclaire Meyer Jan 1987

The Mouse Major Histocompatibility Complex And Age-Related Changes In The Murine Immune System , Terry Euclaire Meyer

Retrospective Theses and Dissertations

A and C57BL/6 inbred mice were used as models for investigating interactions between aging processes and the genes that regulate the immune system, the major histocompatibility complex (MHC, H-2) genes. The C57BL/6 (H-2[superscript] b) mice exhibited significantly longer mean lifespans than the A (H-2[superscript] a) mice, as has been observed by other investigators. Backcross and F[subscript] 2 generation offspring from the parental A and C57BL/6 mice were tested for dependence of longevity upon H-2 type. The effects of H-2 type upon lifespan were statistically significant only for the oldest surviving (i.e., "10[superscript ...