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Molecular Biology Commons

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Theses/Dissertations

Graduate Theses and Dissertations

2014

Chemistry

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Studies Of Integrins' Lateral Dynamics At A Single Particle Level, Dipak Mainali Jan 2014

Studies Of Integrins' Lateral Dynamics At A Single Particle Level, Dipak Mainali

Graduate Theses and Dissertations

One of the important factors in controlling the dynamics, structure, and functioning of the cell membrane is the lateral diffusion of membrane proteins and lipids. Integrins are one of the ubiquitous transmembrane proteins that are vital for numerous cellular functions. Integrins' lateral mobility and rearrangement is essential for integrins primary function of cell-extracellular matrix adhesion, cell-cell adhesion, and signaling. Lateral movement allows integrins to associate with extracellular ligand and other cytoplasmic and membrane proteins to incite biological activity such as signaling and downstream effects. This thesis describes the role of both downstream and upstream effectors, such as extracellular ligand, selected ...