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Full-Text Articles in Molecular Biology

A Single Molecular Study Of The Regulation Of Snare-Mediated Membrane Fusion, Jaekyun Song Jan 2014

A Single Molecular Study Of The Regulation Of Snare-Mediated Membrane Fusion, Jaekyun Song

Graduate Theses and Dissertations

The presynaptic membrane fusion is mediated by a protein set called SNARE (Soluble NSF Attachment protein REceptor) proteins. SNARE proteins form a ternary SNARE-complex that comprises minimal machinery for membrane fusion; the complex consists of three SNARE proteins: Syntaxin 1, SNAP-25 and Vamp 2, also called Synaptobrevin 2. The SNARE complex is a four-helix coiled coil with four SNARE motifs; two come from SNARE-25 and one each from Syntaxin 1 and Vamp 2. It is believed that a regulatory protein Complexin binds tightly to the SNARE complex and stabilizes the complex, preventing it from driving toward fusion. However, the detailed ...


Studies Of Integrins' Lateral Dynamics At A Single Particle Level, Dipak Mainali Jan 2014

Studies Of Integrins' Lateral Dynamics At A Single Particle Level, Dipak Mainali

Graduate Theses and Dissertations

One of the important factors in controlling the dynamics, structure, and functioning of the cell membrane is the lateral diffusion of membrane proteins and lipids. Integrins are one of the ubiquitous transmembrane proteins that are vital for numerous cellular functions. Integrins' lateral mobility and rearrangement is essential for integrins primary function of cell-extracellular matrix adhesion, cell-cell adhesion, and signaling. Lateral movement allows integrins to associate with extracellular ligand and other cytoplasmic and membrane proteins to incite biological activity such as signaling and downstream effects. This thesis describes the role of both downstream and upstream effectors, such as extracellular ligand, selected ...