Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Theses/Dissertations

Graduate Theses and Dissertations

Neuroscience and Neurobiology

Gene therapy

Articles 1 - 1 of 1

Full-Text Articles in Molecular Biology

Prokineticin-2: A Novel Anti-Apoptotic And Anti-Inflammatory Signaling Protein In Parkinson’S Disease, Matthew Neal Jan 2016

Prokineticin-2: A Novel Anti-Apoptotic And Anti-Inflammatory Signaling Protein In Parkinson’S Disease, Matthew Neal

Graduate Theses and Dissertations

The mechanisms behind the development and progression of Parkinson’s disease (PD) are still not fully understood. Several pathophysiological mechanisms have been implicated in the progression of the disease including oxidative stress, mitochondrial dysfunction, excitotoxicity, protein aggregation, and neuroinflammation. Since current therapeutic options for PD treat only the symptoms without influencing disease progression, recent translational studies have focused on identifying factors that protect against putative pathophysiological mechanisms of PD. We show herein, that the chemokine-like signaling protein, Prokineticin-2 (PK2), is expressed and secreted at higher levels in dopaminergic neurons during the acute phase of inflammatory or neurotoxic stress. Furthermore, we ...