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Molecular Biology Commons

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Theses/Dissertations

Graduate Theses and Dissertations

Cell Biology

DNA repair

2015

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Full-Text Articles in Molecular Biology

Regulation And Targeting Of The Fancd2 Activation In Dna Repair, Valentina Celeste Caceres Jan 2015

Regulation And Targeting Of The Fancd2 Activation In Dna Repair, Valentina Celeste Caceres

Graduate Theses and Dissertations

Fanconi anemia (FA) is a genome instability syndrome that is clinically manifested by bone marrow failure, congenital defects, and elevated cancer susceptibility. The FA pathway is known to regulate the repair of DNA interstrand crosslinks in part through DNA homologous recombination (HR) repair. Up to today 16 FA proteins have been discovered that may participate in the common pathway. Cells that have mutations in the FA genes are hypersensitive to DNA damaging agents and display chromosome instability. A key regulatory event in the FA pathway is monoubiquitination of FANCD2-FANCI heterodimer that is mediated by a multi-component E3 ubiquitin ligase complex ...