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- Keyword
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- Conserved Region 3 (1)
- E1A (1)
- Heterotrimeric G proteins; Regulator of G protein signalling proteins (RGS proteins); Gi/o-Loco interacting motif (GoLoco motif); GTPase accelerating proteins (GAPs); Guanine nucleotide dissociation inhibitors (GDIs); Protein-protein interaction (1)
- Human adenovirus (1)
- Protein-protein interactions (1)
Articles 1 - 2 of 2
Full-Text Articles in Molecular Biology
Regulation Of G Protein Signaling By Goloco Motif Containing Proteins, Peishen Zhao
Regulation Of G Protein Signaling By Goloco Motif Containing Proteins, Peishen Zhao
Electronic Thesis and Dissertation Repository
Signal transduction via heterotrimeric G proteins in response to transmembrane G protein-coupled receptors plays a central aspect in how cells integrate extracellular stimuli and produce biological responses. In addition to receptor-mediated activation of heterotrimeric G proteins, during the last few decades, accessory proteins have been found to regulate G protein activity via different mechanisms. Several proteins have been identified that contain multiple G protein regulatory domains. Using various molecular and biochemical approaches, we have characterized the effects of two such proteins, G18 and RGS14, on G protein activity. Both proteins contain a second G protein binding domain in addition to …
Transactivation By Human Adenovirus Early Region 1a-Conserved Region Three, Jailal Ng Ablack
Transactivation By Human Adenovirus Early Region 1a-Conserved Region Three, Jailal Ng Ablack
Electronic Thesis and Dissertation Repository
One of the critical functions of human adenovirus (hAd) early region 1A (E1A) protein is to activate transcription of the early viral genes. The largest isoform of E1A contains a unique region termed conserved region 3 (CR3), which includes a Cysteine-4 (C4) zinc finger domain. This region activates viral gene expression by interacting with and recruiting cellular transcription machinery to the regulatory regions of early viral genes. Although this process has been studied at length with hAd type 5 E1A, far less is known about how the E1A proteins from other hAd types activate transcription. There are dramatic differences in …