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Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Conference

University of Nebraska at Omaha

2019

Articles 1 - 1 of 1

Full-Text Articles in Molecular Biology

Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Matthew M. Froid Mar 2019

Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Matthew M. Froid

Student Research and Creative Activity Fair

Properties emerge from the dynamics of large-scale molecular networks that are not discernible at the individual gene or protein level. Mathematical models - such as probabilistic Boolean networks - of molecular systems offer a deeper insight into how these emergent properties arise. Here, we introduce a non-linear, deterministic Boolean model of protein, gene, and chemical interactions in human macrophage cells during HIV infection. Our model is composed of 713 nodes with 1583 interactions between nodes and is responsive to 38 different inputs including signaling molecules, bacteria, viruses, and HIV viral particles. Additionally, the model accurately simulates the dynamics of over 50 different ...