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Full-Text Articles in Molecular Biology

Investigating How Cmvil-10 Isoforms Differ In Cell Signaling And Receptor Engagement, Alec Starzinski Apr 2016

Investigating How Cmvil-10 Isoforms Differ In Cell Signaling And Receptor Engagement, Alec Starzinski

Creative Activity and Research Day - CARD

Human Cytomegalovirus (HCMV) is a herpesvirus that infects a majority of the world’s population. There are many viral gene products that aid in virus infection and the establishment of the lifelong latency. UL111A, is a viral gene which, through alternate intron splicing, codes for two protein products cmvIL-10 and LAcmvIL-10 that mimic the structure of human interleukin-10 (hIL-10) to varying degrees. cmvIL-10 has been shown to have a wide range of physiological effects, whereas the effects of LAcmvIL-10 appear to be much more limited in scope. This study seeks to measure the expression levels of LAcmvIL-10 during lytic infection ...