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Investigating The Metal Binding Sites In Znta, A Zinc Transporting Atpase, Sandhya Muralidharan
Investigating The Metal Binding Sites In Znta, A Zinc Transporting Atpase, Sandhya Muralidharan
Wayne State University Dissertations
ZntA from Escherichia coli is a member of the PIBtype ATPase family of transporters. The PIB-type ATPase pumps maintain cellular homeostasis of heavy metals such as Zn2+, Co2+, Cu2+, Cu+, and mediate resistance to toxic metals such as Pb2+, Cd2+ and Ag+. ZntA confers resistance to Pb2+, Cd2+, and Zn2+ by pumping these ions out of the cytoplasm. ZntA has two metal binding sites, one in the hydrophilic N-terminal domain and the other in the transmembrane region. The …