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University of Massachusetts Medical School Faculty Publications

Alternative splicing

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Hnrnp A1 And Secondary Structure Coordinate Alternative Splicing Of Mag, Nancy R. Zearfoss, Emily S. Johnson, Sean P. Ryder Jul 2013

Hnrnp A1 And Secondary Structure Coordinate Alternative Splicing Of Mag, Nancy R. Zearfoss, Emily S. Johnson, Sean P. Ryder

University of Massachusetts Medical School Faculty Publications

Myelin-associated glycoprotein (MAG) is a major component of myelin in the vertebrate central nervous system. MAG is present in the periaxonal region of the myelin structure, where it interacts with neuronal proteins to inhibit axon outgrowth and protect neurons from degeneration. Two alternatively spliced isoforms of Mag mRNA have been identified. The mRNA encoding the shorter isoform, known as S-MAG, contains a termination codon in exon 12, while the mRNA encoding the longer isoform, known as L-MAG, skips exon 12 and produces a protein with a longer C-terminal region. L-MAG is required in the central nervous system. How inclusion of ...