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University of Massachusetts Medical School Faculty Publications

Adipogenesis

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Full-Text Articles in Molecular Biology

Distinct Adipocyte Progenitor Cells Are Associated With Regional Phenotypes Of Perivascular Aortic Fat In Mice, Khanh-Van T. Tran, Timothy P. Fitzgibbons, So Yun Min, Tiffany Desouza, Silvia Corvera Mar 2018

Distinct Adipocyte Progenitor Cells Are Associated With Regional Phenotypes Of Perivascular Aortic Fat In Mice, Khanh-Van T. Tran, Timothy P. Fitzgibbons, So Yun Min, Tiffany Desouza, Silvia Corvera

University of Massachusetts Medical School Faculty Publications

OBJECTIVE: Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). It is not known whether this distinction is due to the in-vivo functional environment or to cell-autonomous traits that persist outside the in-vivo setting. In this study, we asked whether the progenitor cells in tPVAT and aPVAT have cell-autonomous traits that lead to formation of regionally distinct PVAT.

METHODS: We performed microarray analysis of thoracic and abdominal peri-aortic adipose ...