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Full-Text Articles in Molecular Biology

A Role For Cell Cycle Protein E2f1 In Hiv-Induced Neurotoxicity, Jacob Zyskind Jan 2015

A Role For Cell Cycle Protein E2f1 In Hiv-Induced Neurotoxicity, Jacob Zyskind

Publicly Accessible Penn Dissertations

HIV-associated neurocognitive disorders (HAND) are a spectrum of HIV-related conditions affecting the central nervous system that range from mild memory impairments to severe dementia. HAND results from the release of inflammatory factors and excitotoxins by HIV-infected macrophages in the brain. These factors alter the extracellular environment and provoke a neuronal response, ultimately causing dendritic damage, synaptic loss, and neuronal death. Our previous data indicate that components of the cell cycle regulatory machinery are elevated in neurons from post-mortem brain tissue of HAND patients. One of these upregulated proteins, the transcription factor E2F1, is known to activate gene targets required for ...


The Identification Of Novel Mechanisms In Neuronal Development And Degeneration, Angela Marie Jablonski Jan 2015

The Identification Of Novel Mechanisms In Neuronal Development And Degeneration, Angela Marie Jablonski

Publicly Accessible Penn Dissertations

The goal of this dissertation is to further understand two key, broad processes which occur over the course of a neuron's lifetime: its development and possible degeneration in disease. We identify novel components in both of these processes and attempt to understand the functional significance as well as the mechanism each component uses to exert its effects.

We begin with work done focusing on how the neuron's dendritic tree develops. The development of neurons has two phases: (1) a first phase relying on a genetic program and (2) a second phase that uses synaptic activity to guide the ...


Change And Impact Of Microrna Modification With Age In Drosophila Melanogaster, Masashi Abe Jan 2013

Change And Impact Of Microrna Modification With Age In Drosophila Melanogaster, Masashi Abe

Publicly Accessible Penn Dissertations

microRNAs (miRNAs) are 20~24nt small RNAs that are critical for many biological aspects, from development to age-associated processes. Starting from the identification of the first miRNA, lin-4, hundreds of miRNAs have been discovered across species. To reveal the role of miRNAs in aging, studies have profiled changes in miRNA levels with age. However, increasing evidence suggests that miRNAs show heterogeneity in length and sequence in different biological contexts. Despite the observation of such heterogeneity, it is largely unknown how such heterogeneity is generated, and whether it is biologically regulated or important. Here we report the characterization of a novel ...