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Molecular Biology Commons

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Publicly Accessible Penn Dissertations

2016

Cholesterol

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Full-Text Articles in Molecular Biology

Mining Genomic Variants And Causal Pathways Linking Hdl And Triglycerides To Coronary Disease, Sumeet Anand Khetarpal Jan 2016

Mining Genomic Variants And Causal Pathways Linking Hdl And Triglycerides To Coronary Disease, Sumeet Anand Khetarpal

Publicly Accessible Penn Dissertations

Blood lipids are important biomarkers of risk of coronary heart disease (CHD), the leading cause of death in the world. Myriad data support a causal role of low-density lipoprotein cholesterol (LDL-C) in increasing risk of CHD. Long-standing epidemiology suggests that high-density lipoprotein cholesterol (HDL-C) may protect from disease while high triglycerides (TGs) increase CHD risk. However, the causality of HDL-C and TG to CHD remains controversial. New genetic methodologies have allowed a better look into causal pathways underlying relationships between these traits and disease. Using a combination of approaches for interrogating rare genetic variation in humans, we investigated how HDL ...