Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Publicly Accessible Penn Dissertations

2016

Neuroscience and Neurobiology

Neurons

Articles 1 - 1 of 1

Full-Text Articles in Molecular Biology

Contextual Insights Into The Rett Syndrome Transcriptome, Brian Scott Roosevelt Johnson Jan 2016

Contextual Insights Into The Rett Syndrome Transcriptome, Brian Scott Roosevelt Johnson

Publicly Accessible Penn Dissertations

Mutations in MECP2 are responsible for Rett syndrome (RTT), a severe X-linked neurological disorder characterized by loss of developmental milestones, intellectual disability and motor impairments. However, molecular insight into how these mutations affect the neuronal transcriptiome, disrupt neuronal function and contribute to RTT is impeded by the cellular heterogeneity of the mammalian brain. A comparison between gene expression changes in the striatum, hypothalamus, and cerebellum of MeCP2-null mice revealed that gene expression changes are distinct between different brain regions, which suggests that MeCP2 function should be understood in a cell type-dependent context. To accomplish this task, I generated and phenotypically ...