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Molecular Biology Commons

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Publicly Accessible Penn Dissertations

2016

Neuroscience and Neurobiology

Molecular Biology

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Multiple Roles Of Ret Signaling In Mechanosensory Neuron Development, Michael Scott Fleming Jan 2016

Multiple Roles Of Ret Signaling In Mechanosensory Neuron Development, Michael Scott Fleming

Publicly Accessible Penn Dissertations

Somatosensation is critical for interaction with the surrounding environment. Somatosensory stimuli are detected by primary somatosensory neurons of the dorsal root ganglia and trigeminal ganglia, which detect distinct classes of stimuli, such as temperature, pain, and pressure. In Chapters 2 and 3 of this thesis, we focus on rapidly adapting low-threshold mechanoreceptors (RALTMRs), which mediate the detection of light touch. RALTMRs are molecularly defined by the early embryonic expression of the receptor tyrosine kinase Ret. Ret is required for the development of central axonal projections of RALTMRs into the dorsal spinal cord. RET responds to the glial cell line-derived family ...