Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Publicly Accessible Penn Dissertations

2016

Medical Specialties

Autoimmunity

Articles 1 - 1 of 1

Full-Text Articles in Molecular Biology

Defining Mechanisms Of Autoimmunity In Pemphigus Vulgaris, Michael Jeffrey Tejada Cho Jan 2016

Defining Mechanisms Of Autoimmunity In Pemphigus Vulgaris, Michael Jeffrey Tejada Cho

Publicly Accessible Penn Dissertations

A prominent question in the field of autoimmunity is how these diseases arise. Currently, the etiologies of many autoimmune diseases remain unclear. The work described here provides insight into this question in the context of pemphigus vulgaris (PV), a prototypic autoimmune disease characterized by serum autoantibodies to desmoglein (Dsg) 3. We utilize a combination of both antibody phage display and heterohybridoma to probe the anti-Dsg3 antibody repertoires of patients with PV. We first address whether a cohort of four patients with active disease demonstrate any shared characteristics in their anti-Dsg3 antibody repertoires (Chapter 2), and if so, why. We find ...