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Molecular Biology Commons

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Publicly Accessible Penn Dissertations

2013

Dauer

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Full-Text Articles in Molecular Biology

Developmental Regulation Of Strongyloides Stercoralis Infectious Third-Stage Larvae By Canonical Dauer Pathways, Jonathan David Chaffee Stoltzfus Jan 2013

Developmental Regulation Of Strongyloides Stercoralis Infectious Third-Stage Larvae By Canonical Dauer Pathways, Jonathan David Chaffee Stoltzfus

Publicly Accessible Penn Dissertations

Parasitic nematodes inflict a vast global disease burden in humans as well as animals and plants of agricultural importance; understanding how these worms infect their hosts has significant health and economic implications. In humans, soil-transmitted parasitic nematodes cause hookworm disease and strongyloidiasis, and vector-transmitted parasitic nematodes cause filariasis. The infectious form of the species causing these diseases is a developmentally arrested third-stage larva (L3i). Molecular mechanisms governing L3i developmental arrest and activation within a host have been poorly understood. An analogous developmentally arrested third-stage larva--the dauer larva--forms during stressful environmental conditions in the free-living nematode Caenorhabditis elegans and is controlled ...