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Molecular Biology Commons

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Publicly Accessible Penn Dissertations

2013

Computational modeling

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Full-Text Articles in Molecular Biology

Regulation Of Egf Receptor Dynamics By Protein Tyrosine Phosphatases, Calixte Monast Jan 2013

Regulation Of Egf Receptor Dynamics By Protein Tyrosine Phosphatases, Calixte Monast

Publicly Accessible Penn Dissertations

The phosphorylated epidermal growth factor receptor (EGFR) initiates intracellular signaling processes that regulate cell growth, survival, and migration, and disregulated EGFR-mediated signaling occurs in many cancers. While the processes that lead to EGFR activation and phosphorylation have been studied in detail, quantitative aspects of the spatiotemporal regulation of EGFR by protein tyrosines phosphatases (PTPs) are not well understood. To begin to address this, we developed a new compartmentalized mechanistic model of EGFR phosphorylation dynamics and used it to interpret quantitative biochemical measurements to show that EGFR is dephosphorylated at the plasma membrane and in the cell interior with a time ...