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Molecular Biology Commons

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Publicly Accessible Penn Dissertations

2013

BMP

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Full-Text Articles in Molecular Biology

Multiple Conserved Enhancers Of The Osteoblast Master Transcription Factor, Runx2, Integrate Diverse Signaling Pathways To Direct Expression To Developing Bone, Christopher Weber Jan 2013

Multiple Conserved Enhancers Of The Osteoblast Master Transcription Factor, Runx2, Integrate Diverse Signaling Pathways To Direct Expression To Developing Bone, Christopher Weber

Publicly Accessible Penn Dissertations

The vertebrate skeleton forms via two distinct modes of ossification, membranous and endochondral. Osteoblasts are also heterogeneous in embryonic origin; bone formed by either mode can be derived from neural crest cells or mesoderm. In contrast, all bone develops via a common genetic pathway regulated by the transcription factor Runx2. Runx2 is required for bone formation, and haploinsufficiency in humans causes the skeletal syndrome cleidocranial dysplasia, demonstrating the importance of gene dosage. Despite the central role of Runx2 in directing bone formation, little is understood about how its expression is regulated in development. We took an unbiased approach to identify ...