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Molecular Biology Commons

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Publicly Accessible Penn Dissertations

2013

Virology

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Full-Text Articles in Molecular Biology

Phenotypic Characteristics Of Mucosally Transmitted Hiv-1, Nicholas F. Parrish Jan 2013

Phenotypic Characteristics Of Mucosally Transmitted Hiv-1, Nicholas F. Parrish

Publicly Accessible Penn Dissertations

Mucosal transmission accounts for the majority of new human immunodeficiency virus type 1 (HIV-1) infections and results in a genetically and phenotypically homogenous founder virus population in 60-80 percent of cases. Biological properties common to these transmitted and founder (T/F) viruses but not chronic control (CC) viruses would define key targets for microbicides and vaccines. To identify such properties, we tested 45 T/F and 52 CC envelope glycoproteins (Envs) from the best studied and most prevalent HIV-1 subtypes (B and C, respectively) in various pseudotype assays to determine their receptor and coreceptor interaction, tropism for primary CD4+ T ...