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Full-Text Articles in Molecular Biology
A Study Of The Therapeutic Potential Of Af4 Mimetic Peptides, Nisha N. Barretto
A Study Of The Therapeutic Potential Of Af4 Mimetic Peptides, Nisha N. Barretto
Dissertations
Mixed lineage leukemias (MLL) are a group of acute and aggressive leukemias. They account for over 70% of infant leukemias, and 10% of acute adult leukemias. Pediatric ALL and therapy related MLL leukemias carry poor prognosis in spite of several advancement in the field of leukemia research. Therefore, new therapies for MLL leukemias are needed.
Majority of MLL leukemias arise due to the balanced translocations of the MLL gene. As a result of these translocations, chimeric MLL fusion proteins are expressed. The most frequently occurring MLL fusion proteins are known to aberrantly recruit the super elongation complex (SEC) resulting in …