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Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Wright State University

2015

Kinesin 13

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Full-Text Articles in Molecular Biology

Identifying The Amino Acids Important For Hiv Rev-Tubulin Interactions, Bruce E. Dukes Ii Jan 2015

Identifying The Amino Acids Important For Hiv Rev-Tubulin Interactions, Bruce E. Dukes Ii

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The Rev protein is Human Immunodeficiency virus's "switch" from events occurring early in infection to later events. Early in infection, the 13 KDa Rev protein begins to accumulate in the host cell nucleus. Once enough Rev is produced, Rev stimulates a switch in viral gene expression by multimerizing onto nuclear viral RNAs and stimulating their export into the cytoplasm. Multimerization occurs on an RNA structure called the Rev Response Element (RRE). Several Rev monomers bind the RRE and once that threshold is met the Rev-RRE complex is exported out of the nucleus. Once out of the nucleus the Rev-RRE ...