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Molecular Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Wright State University

2015

DNA Extraction

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Full-Text Articles in Molecular Biology

Improving Dna Quality Using Ffpe Tissues For Array Comparative Genomic Hybridization To Find Single Nucleotide Polymorphisms (Snps) In Melanoma, Keerti Potluri Jan 2015

Improving Dna Quality Using Ffpe Tissues For Array Comparative Genomic Hybridization To Find Single Nucleotide Polymorphisms (Snps) In Melanoma, Keerti Potluri

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Important classes of benign and malignant neoplasms are composed of melanocytic cells which produce a pigment called melanin. Benign nevi, which are non-malignant melanocytic lesions, can sometimes give rise to malignant melanoma. Melanoma can be a lethal melanocytic neoplasm, a deadly and aggressive form of skin cancer. Finding prognostic or diagnostic markers can be very useful to reduce the deaths caused by melanoma. Array Comparative Genomic Hybridization (aCGH), a cytogenetic technique, analyzes the whole genome or chromosome for detecting genetic aberrations/variations such as single nucleotide polymorphisms (SNPs) in a cancer. formalin fixed paraffin embedded FFPE tissues are usually taken ...