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Wright State University

Theses/Dissertations

Benign Nevi

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Distinguishing Melanocytic Nevi From Melanoma By Dna Copy Number Changes: Array-Comparative Genomic Hybridization As A Research Tool, Ahmed Ibrahim Mahas Jan 2015

Distinguishing Melanocytic Nevi From Melanoma By Dna Copy Number Changes: Array-Comparative Genomic Hybridization As A Research Tool, Ahmed Ibrahim Mahas

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Skin melanocytes can give rise to different benign and malignant neoplasms. Discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. However, previous studies have shown that in contrast to benign nevi, melanoma demonstrates pervasive chromosomal aberrations. This substantial difference between melanoma and benign nevi formed the idea of exploiting this difference to discriminate between melanoma and benign nevi. Array-comparative genomic hybridization (aCGH) is an approach that can be used on DNA extracted from formalin-fixed paraffin-embedded (FFPE) tissues to assess the entire genome for the presence of changes in DNA copy number. In this ...