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Full-Text Articles in Molecular Biology

Availability Of Fermentable Nutrients Affect Gut Microbiota Composition, Trupthi Mehta Jan 2018

Availability Of Fermentable Nutrients Affect Gut Microbiota Composition, Trupthi Mehta

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Recent studies have increasingly established the role of gut microbiota in human health and disease. Diseases such as inflammatory bowel disease, colon cancer, cardiovascular disease and many neurological disorders have been linked to specific gut microbiota composition and disturbances. There have also been attempts in recent years to modulate gut microbial composition with the use of prebiotics and probiotics to promote healthy gut and prevent diseases. This thesis investigates whether the availability of fermentable nutrients high in fiber and antioxidants such as found in green coffee, roasted coffee, and salami infused with various prebiotics altered the composition and abundance of ...


A Novel Method To Analyze Dna Breaks And Repair In Human Cells, Caitlin Elizabeth Goodman Jan 2018

A Novel Method To Analyze Dna Breaks And Repair In Human Cells, Caitlin Elizabeth Goodman

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Microsatellites repeat sequences are prone to forming non-canonical DNA structures and mutations. These areas of the genome can undergo expansions and contractions and are responsible for a variety of inherited neurological and neuromuscular disorders. Hairpin structures formed by trinucleotide repeats can lead to replication fork stalling, and fork collapse causing DNA double strand breaks. Various mechanisms are involved in processing microsatellites including mismatch repair, base excision repair, and crossover junction endonuclease cleavage. These processes, which are supposed to protect the genome, could also be the culprits which are causing mutations. In order to test and study this hypothesis, the use ...