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Full-Text Articles in Molecular Biology
Alignment Of Mitotic Chromosomes In Human Cells Involves Sr-Like Splicing Factors Btf And Trap150, Sapna Varia, Divya Cheedu, Michael P. Markey, Keshia Torres-Shafer, Vishnu P. Battini, Athanasios Bubulya, Paula A. Bubulya
Alignment Of Mitotic Chromosomes In Human Cells Involves Sr-Like Splicing Factors Btf And Trap150, Sapna Varia, Divya Cheedu, Michael P. Markey, Keshia Torres-Shafer, Vishnu P. Battini, Athanasios Bubulya, Paula A. Bubulya
Biochemistry and Molecular Biology Faculty Publications
Serine-arginine-rich (SR) or SR-like splicing factors interact with exon junction complex proteins during pre-mRNA processing to promote mRNA packaging into mature messenger ribonucleoproteins (mRNPs) and to dictate mRNA stability, nuclear export, and translation. The SR protein family is complex, and while many classical SR proteins have well-defined mRNA processing functions, those of other SR-like proteins is unclear. Here, we show that depletion of the homologous non-classical serine-arginine-rich (SR) splicing factors Bcl2-associated transcription factor (Btf or BCLAF) and thyroid hormone receptor-associated protein of 150 kDa (TRAP150) causes mitotic defects. We hypothesized that the depletion of these SR-like factors affects mitosis indirectly …