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Dna Glycosylases Remove Oxidized Base Damages From G-Quadruplex Dna Structures, Jia Zhou
Dna Glycosylases Remove Oxidized Base Damages From G-Quadruplex Dna Structures, Jia Zhou
Graduate College Dissertations and Theses
The G-quadruplex DNA is a four-stranded DNA structure that is highly susceptible to oxidation due to its G-rich sequence and its structure. Oxidative DNA base damages can be mutagenic or lethal to cells if they are left unrepaired. The base excision repair (BER) pathway is the predominant pathway for repair of oxidized DNA bases. DNA glycosylases are the first enzymes in BER and are responsible for removing base lesions from DNA. How DNA glycosylases remove base lesions from duplex and single-stranded DNA has been intensively studied, while how they act on G-quadruplex DNA remains to be explored.
In Chapter II …