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Articles 1 - 3 of 3
Full-Text Articles in Molecular Biology
Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Matthew M. Froid
Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Matthew M. Froid
UNO Student Research and Creative Activity Fair
Properties emerge from the dynamics of large-scale molecular networks that are not discernible at the individual gene or protein level. Mathematical models - such as probabilistic Boolean networks - of molecular systems offer a deeper insight into how these emergent properties arise. Here, we introduce a non-linear, deterministic Boolean model of protein, gene, and chemical interactions in human macrophage cells during HIV infection. Our model is composed of 713 nodes with 1583 interactions between nodes and is responsive to 38 different inputs including signaling molecules, bacteria, viruses, and HIV viral particles. Additionally, the model accurately simulates the dynamics of over …
Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater
Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater
Posters-at-the-Capitol
Immunotherapy strategies are very promising treatments for cancer patients. Specifically, Immune checkpoint inhibitor therapy focusing on the PD-1/PD-L1 pathway shows long-lasting positive results in many cancer patients. Unfortunately, not all the patients can benefit from this highly effective treatment. Hence, there is a great need for predictive biomarkers. Immunohistochemical (IHC) staining has been used as a way of predicting patient response, yet shows many problems. For example, IHC utilizes an invasive biopsy and sample fixing, which creates an incomplete and delayed picture of the patient’s biochemistry and the tumor microenvironment, consequently ignoring metastases.
The purpose of this study is to …
Analysis Of The Chondroitinase Operon Of Flavobacterium Columnare, Erin L. Sorlien
Analysis Of The Chondroitinase Operon Of Flavobacterium Columnare, Erin L. Sorlien
Senior Honors Projects
Analysis of the chondroitinase operon of Flavobacterium columnare
Erin Sorlien
Major
Cell and Molecular Biology, Chemistry
Advisor
Dr. David R. Nelson
Date
May 2, 2013
Keywords
Flavobacterium columnare, columnaris disease, chondroitin AC lyase, complementation, csl operon
Abstract
Flavobacterium columnare, an opportunistic bacterial pathogen of fish, is the causative agent of columnaris disease (CD). The bacterium is a Gram-negative rod that exhibits gliding motility and avidly forms biofilms. CD affects both wild and cultured freshwater fish, and continues to cause large economic losses to the fish farming industry. According to an investigation conducted by the National Animal Health Monitoring System, CD …