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Articles 1 - 9 of 9
Full-Text Articles in Molecular Biology
Upregulation Of The Predominant Cystic Fibrosis Causing Mutation Df508-Cftr By Triazole Compounds In Epithelial Cells, Maggie Taylor
Upregulation Of The Predominant Cystic Fibrosis Causing Mutation Df508-Cftr By Triazole Compounds In Epithelial Cells, Maggie Taylor
Undergraduate Research Conference
Cystic fibrosis is a common genetic disease that is caused by a mutation in the plasma membrane protein CFTR, which stands for Cystic Fibrosis Transmembrane-conductance Regulator. When this membrane protein is mutated, it impairs its chloride ion channel function, blocking the movement of chloride ions that travel in and out of the cell. Previous studies have demonstrated that the most prevalent CFTR mutation, ∆F508-CFTR, can be partially reversed using small molecules (Heda and Marino, BBRC, 271:659-664, 2000). In this study, I have investigated the effects of several triazole compounds known to bind and transport chloride ions in cultured cells, on …
Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing
Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing
Andrews Research Conference
Streptococcus mutans JH1140 is a strain of bacteria which produces a lantibiotic product, named mutacin 1140. Mutacin 1140 has been shown to be effective at inhibiting Gram-positive bacterial infections caused by Staphylococcus aureus and Streptococcus pneumoniae. Mutacin 1140 is a ribosomally synthesized peptide antibiotic that undergoes extensive posttranslational modifications (PTM). We have found that Mutacin 1140 and an aminoglycoside, Kanamycin, when combined together, act synergistically against Staphylococcus aureus. This was determined by performing serial kill curve dilution overlays on solid media, followed up with kill curve by microdilution plate, and most recently confirmed with kill curve CFU count plates …
Epigenetic Regulation Of Gene Expression During Spermatogenesis, Karishma Nayak
Epigenetic Regulation Of Gene Expression During Spermatogenesis, Karishma Nayak
Senior Honors Projects
In the US livestock production industry, improving reproductive efficiency will improve animal welfare and maintain reasonable costs of meat and milk for consumers. In recent research, abnormalities in epigenetic markers in sperm during spermatogenesis, has been linked to male subfertility in many species. Epigenetics is the study of changes in organisms caused by modifications of gene expression, including DNA methylation, rather than alteration of the genetic code itself. When this process is disturbed, it can negatively impact semen therefore decreasing its fertility. Through further research on how DNA methylation influences gene expression during spermatogenesis and its impact on sperm quality, …
Requirements Of Rab5 Activity In Highly Invasive Breast Cancer Cell Lines, Nicole Porther, M Alejandro Barbieri
Requirements Of Rab5 Activity In Highly Invasive Breast Cancer Cell Lines, Nicole Porther, M Alejandro Barbieri
Nicole Porther
Rab5 Function In Breast Cancer Cells, Nicole Porther, M Alejandro Barbieri
Rab5 Function In Breast Cancer Cells, Nicole Porther, M Alejandro Barbieri
Nicole Porther
Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt
Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt
Maxine G Schmidt
Presentation delivered to librarians in China, Japan and South Korea as part of my sabbatical research on the use of libraries by Asian students in their home countries.
Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt
Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt
Maxine G Schmidt
No abstract provided.
Umass Libraries 2009, Maxine G. Schmidt
Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt
Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt
Maxine G Schmidt
No abstract provided.